ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: firstname.lastname@example.org
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $67.5 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2015, 20(10):19172-88Molecules.2015, 20(11):20014-30Chemistry of Plant Materials....2016...J Chromatogr B Analyt Technol Bio...2017...J. of The Korean Society of Food ...2017...J Bone Miner Res.2017, 32(12):2415-2430Chem Biol Interact.2018, 290:44-51J Sep Sci.2018, 41(7):1682-1690
International J of Green Pharmacy...2019...J Pharm Biomed Anal.2019, 172:268-277J Med Food.2019, 22(10):1067-1077J Ethnopharmacol.2019, 236:31-41Molecules.2019, 24(21):E3834Food Chem.2019, 290:286-294Int J Immunopathol Pharmacol....2019...Kor. J. Herbol.2019, 34(2):59-66
Academic J of Second Military Med...2019...Food and Fermentation Industries...2019...Anal Biochem.2019, 569:10-15Phytomedicine.2019, 61:152813Biomolecules.2019, 9(11):E696Biosci. Rep.2020, 10.1024Antioxidants (Basel).2020, 9(2):E120
Our products had been exported to the following research institutions and universities, And still growing.
University of Canterbury (New Zealand)University of Stirling (United Kingdom)Biotech R&D Institute (USA)Deutsches Krebsforschungszentrum (Germany)
Nanjing University of Chinese M... (China)Instytut Nawozów Sztucznych w ... (Poland)Rio de Janeiro State University (Brazil)University of Ioannina (Greece)
University of Malaya (Malaysia)Anna University (India)Funda??o Universitária de Dese... (Brazil)
Related Screening Libraries
||Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities, it shows significant antiproliferative activity against the HepG-2, MCF-7 and C6 cancer cell lines. |
||Immunology & Inflammation related|
|Planta Med. 2010 Jan;76(1):82-5. |
|Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines.[Pubmed: 19653148]|
|Bioassay-guided fractionation of the antiproliferative chloroform extract of the traditional Chinese medicine Qiang-Huo (Notopterygium incisum) led to the isolation of nine linear furocoumarins (1- 9). |
METHODS AND RESULTS:
All the isolates were tested against two human cancer cell lines (HepG-2 and MCF-7) and a rat cancer cell line (C6) using the MTT assay method. Among them, notopol (1), Notopterol (2), 5-[(2 E,5 Z)-7-hydroxy-3,7-dimethyl-2,5-octadienoxy]psoralene (3), and 5-[(2,5)-epoxy-3-hydroxy-3,7-dimethyl-6-octenoxy]psoralene (4) showed significant antiproliferative activity against the HepG-2 and C6 cancer cell lines, with IC(50) values of 7.7-24.8 microg/mL (5-FU: ca. 5 microg/mL). Compounds 1- 3 also showed moderate cytotoxicity against the MCF-7 cancer cell line, with IC(50) values of 39.4-61.3 microg/mL (5-FU: 17.3 microg/mL). The cell cycle-specific inhibition and apoptosis induced by compounds 1 and 2 were determined using flow cytometry.
The structure-activity relationship (SAR) is briefly discussed herein. It was found that the presence of a free hydroxy at the lipophilic side chain linked to C-5 of the linear furocoumarins was essential for their in vitro antiproliferative activity.
|Chem Pharm Bull (Tokyo). 1993 May;41(5):926-9. |
|Analgesic component of Notopterygium incisum Ting.[Pubmed: 8339339]|
METHODS AND RESULTS:
Notopterol was identified as the analgesic component of Notopterygium incisum TING by using the acetic acid-induced writhing method. Notopterol also indicated an anti-inflammatory activity by its inhibitory effect in the vascular permeability test. The intensive prolongation of pentobarbital-induced hypnosis was possibly caused by its inhibitory effect on the drug metabolism in liver. Pharmacological differences between the analgesic components of N. incisum, Aralia cordata and Angelica pubescens were also discussed.
||The roots of Notopterygium incisum.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.