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    Triptoquinone B
    Information
    CAS No. 142937-50-6 Price
    Catalog No.CFN99474Purity>=98%
    Molecular Weight330.4 Type of CompoundDiterpenoids
    FormulaC20H26O4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells.
    2. Triptoquinone B shows the significant immunosuppressive activity.
    Targets: IL Receptor
    Triptoquinone B Description
    Source: The vines of Tripterygium wilfordii
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0266 mL 15.1332 mL 30.2663 mL 60.5327 mL 75.6659 mL
    5 mM 0.6053 mL 3.0266 mL 6.0533 mL 12.1065 mL 15.1332 mL
    10 mM 0.3027 mL 1.5133 mL 3.0266 mL 6.0533 mL 7.5666 mL
    50 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.2107 mL 1.5133 mL
    100 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.6053 mL 0.7567 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Triptoquinone B References Information
    Citation [1]

    Tetrahedron Letters Volume 38, Issue 23, 9 June 1997, Pages 4121–4124

    Enantiocontrolled total synthesis of the diterpenoids, triptoquinone B, C and triptocallol[Reference: WebLink]
    An efficient and enantiocontrolled synthesis of Triptoquinone B and C, which possess interleukin-1 inhibitory activity, has been accomplished employing the lipase-catalyzed kinetic resolution and a highly diastereoselective radical cyclization as key synthetic steps. In addition, the first total synthesis of triptocallol has been achieved utilizing the same strategy.
    Citation [2]

    Chinese Traditional & Herbal Drugs, 2007, 38(4):493-6.

    Diterpenoids possessed immunosuppressive activity from Tripterygium hypoglaucum.[Reference: WebLink]
    To study the diterpenoids possessed immunosuppressive activity from Tripterygium hypoglaucum. Methods: The chemical constituents were isolated from the CHCl3 extracts of T. hypoglaucum by repeated column chromatography, including silica gel, Sephadex LH-20, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic studies. The immunosuppressive activity of these compounds was tested using the lymphocyte transformation test. Results: Compounds I-VI were identified as triptobenzene H (I), triptoquinone A (II), Triptoquinone B (IIII), triptoquinone H (IV), triptonediol (V), triptonoterpene (VI). Conclusion: Compound I-III are isolated from this medicinal plant for the first time and all the compounds show the significant immunosuppressive activity.