Bioactive Products
| A unique collection of 552 Anti-inflammatory natural compound library for Anti-inflammatory screening and New Anti-inflammatory drug research | ||
| Catalog No: | B72a26 | Anti-inflammatory Compound Library Screening Details |
| Size: | 1mg/well * 552 Compounds 2mg/well * 552 Compounds | |
| Cat. No. | Information |
| CFN98736 | Aromadendrin Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells. Aromadendrin treatment induces adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance, suggests that it may represent a potential therapeutic candidate for the management of type 2 DM. Aromadendrin has inhibitory activity on aldose reductase and the formation of advanced glycation end products. |
| CFN98738 | Linarin Linarin possesses analgesic, antipyretic, anti-acetylcholinesterase, hepatoprotective ,anti-inflammatory and neuroprotective activities, it prevents Aβ(25-35)-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3β and up-regulates Bcl-2. Linarin can protect osteoblasts against hydrogen peroxide-induced osteoblastic dysfunction and may exert anti-resorptive actions, at least in part, via the reduction of RANKL and oxidative damage; it also can treat postmenopausal osteoporosis,it induces the osteogenic differentiation and mineralization of MC3T3-E1 osteoblastic cells by activating the BMP-2/RUNX2 pathway through PKA signalingin vitroand protected against OVX-induced bone lossin vivo. |
| CFN98739 | Pinostrobin Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. Pinostrobin has anti-inflammatory, anti-hemorrhagic and analgesic activity, it can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 ug/ml. |
| CFN98740 | Pinocembrin Pinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, neuroprotective, anti-inflammatory, antioxidant, and anticancer activities. Pinocembrin inhibited LPS-induced inflammatory mediators production by suppressing PI3K/Akt/NF-κB signaling pathway, it also inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of Y-79 cells by inactivating the αvβ3 integrin/FAK/p38α signaling pathway. |
| CFN98741 | Chrysin Chrysin, a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant , anti-inflammation, anti-cancer, hepatoprotective, and anti-oxidation properties. Chrysin induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells; it prevented the development of DN in HFD/STZ-induced type 2 diabetic rats through anti-inflammatory effects in the kidney by specifically targeting the TNF-α pathway. |
