Bioactive Products
A unique collection of 129 Cytotoxic natural compounds used for Cytotoxic research | ||
Catalog No: | B913 | Cytotoxic Compound Library Screening Details |
Size: | 1mg/well * 129 Compounds 2mg/well * 129 Compounds |
Cat. No. | Information |
CFN97233 | Obacunone Obacunone is a novel activator of Nrf2, which exhibits anti-cancer, anti-inflammatory, antivirulence, insecticidal, anti-proliferative and anti-aromatase activities. Obacunone stimulates muscle hypertrophy and prevents obesity and hyperglycemia, and that these beneficial effects are likely to be mediated through the activation of TGR5 and inhibition of PPARγ transcriptional activity. Obacunone significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM, and it also inhibits the p38 MAPK signaling pathway. |
CFN97237 | Cedrusin Cedrusin shows a cytotoxic effect on A375 and HeLa cells. |
CFN97245 | Lupalbigenin Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.Lupalbigenin, laburnetin , and isolupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). |
CFN97249 | Camptothecin Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM; it is a novel alkaloidal leukemia and tumor inhibitor, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA. Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production. |
CFN97254 | Garcinone C Garcinone C is a potent inhibitor of AChE. It is an active compound against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). Garcinone C exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro. |