Natural Products
Aconine
| Catalog No. | CFN90248 |  |
| CAS No. | 509-20-6 | |
| Molecular Weight: | 499.60 | |
| Molecular Formula | C25H41NO9 | |
| DBs | [PubChem]:274954967 [ChEMBL]:132639 [PCIDB]: |
Standard InChI:
InChI=1S/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12-,13+,14-,15?,16+,17-,18-,19-,20+,21+,22+,23-,24+,25-/m1/s1
Biological Activity
Aconine can inhibit RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression.[1]
Aconine has GW26-e4470 effect on the expression of Sirt-1 and eNOS system in EAhy926 cell injured by Homocysteine.[2]
Aconine can attenuate hepatic fat degeneration of rats with fatty liver induced by high-fat diet through decreasing TG,TC deposit in liver.[3]
Product
References
[1] Zeng X Z, He L G, Wang S, et al. Acta Pharmacol Sin, 2015, 37(2):255-63.
[2] Liu Y, Zheng Z, Zhou B, et al. J Am Coll Cardiol, 2015, 66(16):C92-3.
[3] Shou Z X, Fan H.Journal of Shandong University of Traditional Chinese Medicine, 2008, 32(2):166-8.
[4] Liu M, Zhang H, Cai Y M, et al.Journal of Pharmaceutical Practice, 2013, 31(3):181-4.
Product Use Citation
