Natural Products
Ganoderic acid Z
| Catalog No. | CFN90295 |  |
| CAS No. | 294674-09-2 | |
| Molecular Weight: | 514.66 | |
| Molecular Formula | C30H42O7 | |
| DBs | [PubChem]:274954924 [ChEMBL]: [PCIDB]: |
Standard InChI:
InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h11,15,17-18,21-22,31,34H,8-10,12-14H2,1-7H3,(H,36,37)/b16-11+/t15-,17?,18-,21?,22+,28+,29-,30+/m1/s1
Biological Activity
Ganoderic acid zeta , isolated from the spores, has cytotoxicity in vitro against Meth-A and LLC cell lines.[1]
The binding affinities of ganoderic acid DM and Z (ΔGbind, −16.83 and−10.99 kcal mol−1) are comparable to that of current commercial drug oseltamivir (−23.62 kcal mol−1);
ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.[2]
Product
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References
[1] Min B S, Gao J J, Nakamura N, et al. Cheminform, 2000, 31(50):1026-33.
[2] Yang Z, Fei W, Yuan X, et al. J Mol Graph Model, 2016, 65:27–34.
[3] B M Li, Gu HF, L i Y, et al. China Journal of Chinese Materia Medica, 2012, 37(23):3599-603.
Product Use Citation
