Natural Products
Ellagic acid
Catalog No. | CFN98716 | |
CAS No. | 476-66-4 | |
Molecular Weight: | 302.2 | |
Molecular Formula | C14H6O8 | |
DBs | [PubChem]:274951788 [ChEMBL]:4775 [PCIDB]:11153 |
Standard InChI:
InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
Biological Activity
Ellagic acid, a naturally occurring plant phenol, inhibits the activity of the direct-acting mutagen N-methyl-N-nitrosourea (MeNU) in Salmonella typhimurium TA100, is due to specific inhibition of methylation at the O6 position of guanine through an ellagic acid-duplex DNA affinity-binding mechanism.[1]
Ellagic acid has anti-oxidant and anti-inflammatory properties, can inhibit key cell functions and activation of PSCs, including platelet-derived growth factor (PDGF)-BB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, alpha-smooth muscle actin and collagen genes. [2]
Ellagic acid has antioxidant and apoptosis-inducing activities, shows high DPPH radical scavenging and peroxidation inhibition activities, significantly reduces HOS cell proliferation, and induces apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance.[3]
Product
References
[1] Dixit R, Gold B. P Natl Acad Sci USA, 1986, 83(21):8039-43.
[2] Masamune A, Satoh M, Kikuta K, et al. Biochem Pharmacol, 2005, 70(6):869-78.
[3] Han D H, Lee M J, Kim J H. Anticancer Res, 2006, 26(5A):3601-6.
[4] Ou L M, Seken A, Li K A, et al. Int J Pharm Res, 2015, 42(05):637-41.
Product Use Citation