Natural Products
Dehydrocostus lactone
Catalog No. | CFN98720 | |
CAS No. | 477-43-0 | |
Molecular Weight: | 230.3 | |
Molecular Formula | C15H18O2 | |
DBs | [PubChem]:274951784 [ChEMBL]:244418 [PCIDB]:3245 |
Standard InChI:
InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
Biological Activity
Dehydrocostus lactone(DCL) is exuded from sunflower roots and low DCL concentrations stimulate germination of the root parasite Orobanche cumana.[1]
Dehydrocostus lactone(0.1-10microg/ml) can protect osteoblasts against H(2)O(2)
-induced cellular dysfunction, may be valuable as a protective agent against oxidative damage in osteoblasts.[2]
Dehydrocostus lactone increases cellular resistance to oxidant injury in HepG2 cells, may via causing the nuclear accumulation of the nuclear factor E2-related factor 2 (Nrf2) and increasing the promoter activity of antioxidant response element (ARE).[3]
Dehydrocostus lactone and costunolide exhibits strong larvicidal activity against A. albopictus with LC(50) values of 2.34 and 3.26 ug/ml, respectively, while the essential oil had an LC(50) value of 12.41 ug/ml. [4]
Product
Official website: Dehydrocostus lactone
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Chinese website: Dehydrocostus lactone
Japanese website: Dehydrocostus lactone
Chinese website: Dehydrocostus lactone
References
[1] El-Nadi M, Zohni O. Phytochemistry, 2011, 72(7):624-34.
[2] Choi E M, Kim G H, Yong S L. Toxicol In Vitro, 2009, 23(5):862-7.
[3] Jeong G S, Pae H O, Jeong S O, et al. Eur J Phamarmacol, 2007, 565(565):37-44.
[4] Zhi L L, He Q, Sha S C, et al. Parasitol Res , 2011, 110(6):2125-30.
[5] Tan S J, Qiu D, Liu G, et al. Chinese Journal of Pharmaceutical Analysis, 2011, 31(1):145-7.
Product Use Citation