Natural Products
Dehydroabietic acid
Catalog No. | CFN99822 | |
CAS No. | 1740-19-8 | |
Molecular Weight: | 300.4 | |
Molecular Formula | C20H28O2 | |
DBs | [PubChem]:274951132 [ChEMBL]:29571 [PCIDB]: |
Standard InChI:
InChI=1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1
Biological Activity
Dehydroabietic acid (DHAA), a major poison to fishes in pulp and paper mill effluents, has toxicological and physiological effects, 20 μg l−1 is close to the “minimum effective concentration” of DHAA to rainbow trout.[1]
Dehydroabietic acid derivatives have been reported to display antisecretory and antipepsin effect in animal models, have gastroprotective activity in the HCl/EtOH-induced gastric lesions in mice as well as for cytotoxicity in human lung fibroblasts (MRC-5) and human epithelial gastric (AGS) cells. [2]
Dehydroabietic acid derivatives have antiulcer activity.[3]
Product
Official website: Dehydroabietic acid
Japanese website: Dehydroabietic acid
Chinese website: Dehydroabietic acid
Japanese website: Dehydroabietic acid
Chinese website: Dehydroabietic acid
References
[1] Oikari A, Lönn B E, Castrén M, et al. Water Res, 1983, 17(1):81-9.
[2] Sepúlveda B, Astudillo L, Rodríguez J A, et al. Pharmacol Res, 2005, 52(5):429-37.
[3] Wada H, Kodato S, Kawamori M, et al. Chem Pharm Bull, 1985, 33(4):1472-87.
[4] K. Hroboňová, Dr. J. Lehotay, I. Skačáni, et al. J Liq Chromatogr R T, 2005, 28(11):1725-35.
Product Use Citation