Lithospermum is a genus of plants belonging to the family Boraginaceae. Herbs or small shrubs, they are widely distributed except in Australasia. Species are known generally as gromwells orstoneseeds. Lithospermum leaves are eaten by the caterpillars of certain Lepidoptera, such as the moth Ethmia pusiella which has been recorded on Common Gromwell (L. officinale).
The dried root of Lithospermum erythrorhizon is a Chinese herbal medicine with various antiviral and biological activities, including inhibition of human immunodeficiency virus (HIV) type 1 (HIV-1).All parts of the plant are antitumor, cardiotonic, contraceptive, depurative and febrifuge. It is used internally in the treatment of irritant skin conditions, measles, chicken pox, boils, carbuncles, hepatitis and skin cancer.

Lithospermum officinale, or gromwell, is a European native while Lithospermum caroliniense, a species of puccoon, is native to North America. Lithospermum purpurocaeruleum is native to Japan, where it has been traditionally been used to make a purple dye.