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Natural Products
Saposhnikovia divaricata

The dry root of Saposhnikovia divaricata (Turcz.) Schischk. (SD, syn. Ledebouriella divaricata (Turcz.); Umbelliferae), Siler, a perennial herb of the carrot family, is also known as Fang Feng in traditional Chinese herbal medicine. It is a herbal ingredient included in many polyherb formulae. This study investigated the in vitro anti-proliferative, antioxidant and anti-inflammatory activities of the SD extract (1 g/10 ml 70% ethanol). IC50 (50% inhibition) is estimated at 1/300, 1/1400, 1/250 and 1/600 dilutions, for the K562, HL60, MCF7 and MDA-MB-468 cell lines, respectively. The combination of non-cytotoxic concentrations of SD with chemotherapeutic drugs such as camptothecin or paclitaxel showed additive anti-proliferative effects on K562, HL60 and MCF7 cells, and antagonistic effects on MDA-MB-468 cells. At a dilution of 1/2000, SD induced a differentiation of 17.5+/-2.5% in HL60 cells along the granulocyte lineage compared to 2.8+/-0.8% in the untreated controls, but not along the monocyte/macrophage lineage.

Saposhnikovia divaricata
Research products of Saposhnikovia divaricata
Catalog Product Name CAS Number Manual
CFN99743Sec-O-Glucosylhamaudol80681-44-3  PDF
CFN98766Bergapten484-20-8  PDF
CFN98016Xanthotoxol2009-24-7  PDF
CFN98372Xanthotoxin298-81-7  PDF
CFN92712Marmesin13710-70-8  PDF
CFN97494Scopoletin92-61-5  PDF
CFN97684Isoscopoletin776-86-3  n/a
CFN99331Vanillic acid121-34-6  PDF
CFN90046D-Mannitol69-65-8  PDF
CFN98970Sucrose57-50-1  n/a
CFN98612Cimifugin37921-38-3  PDF
CFN98104Prim-O-glucosylcimifugin80681-45-4  PDF
CFN981065-O-Methylvisammioside84272-85-5  PDF
CFN98713Daucosterol474-58-8  PDF
CFN99916Beta-Sitosterol83-46-5  PDF
CFN97142Psoralen66-97-7  PDF
CFN98758Imperatorin482-44-0  PDF
CFN90495Phellopterin2543-94-4  PDF
CFN93212Panaxynol81203-57-8  n/a
CFN98220Falcarindiol225110-25-8  PDF
CFN99537beta-Eudesmol473-15-4  PDF
CFN99637Cimiside B152685-91-1  PDF
CFN97716Demethoxycapillarisin61854-36-2  n/a
CFN90481Cimicifugoside66176-93-0  n/a
CFN96027Falcarinol21852-80-2  PDF
CFN90976Cimifugin 4'-O-beta-D-glucopyranoside1632110-81-6  n/a
CFN909826-O-apiosyl-5-O-Methylvisammioside139446-82-5  n/a
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