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Natural Products
Siegesbeckia pubescens Makino
Siegesbeckia pubescens (S. pubescens) was widely used to alleviate symptoms of osteoarthritis (OA) in traditional medicine.
Three new ent-kaurane-type diterpenoids, siegesbeckioside, siegesbeckiol and siegesbeckic acid, were isolated together with five known diterpenes from Siegesbeckia pubescens (Xi-Xian). On the basis of chemical and spectral evidences, their structures were elucidated as ent-16β,17,18-trihydroxy-kauran 18-O-β-d-glucopyranoside, ent-kauran-2α,16β,17-triol, ent-16α,17,18-dihydroxy-kauran-19-oic acid, ent-kauran-16β,17,18-triol, ent-16β,17-dihydroxy-kauran-19-oic acid, ent-16α,17-hydroxy-kauran-19-oic acid, grandifloric acid and kirenol, respectively.
A novel HPLC method was developed for the simultaneous quantification of seven major diterpenoids of two types, including ent-pimarane type: Kirenol, Hythiemoside B, Darutigenol, and ent-kaurane type: ent-16β,17,18-trihydroxy-kauran-19-oic acid, ent-17,18-dihydroxy-kauran-19-oic acid, ent-16β,17-dihydroxy-kauran-19-oic acid, 16α-hydro-ent-kauran-17,19-dioic acid in the aerial parts of Siegesbeckia pubescens.
Siegesbeckia pubescens Makino
Research products of Siegesbeckia pubescens Makino
Catalog Product Name CAS Number Manual
CFN97004Darutoside59219-65-7  PDF
CFN97006Darutigenol5940-00-1  PDF
CFN98867Kirenol52659-56-0  PDF
CFN98424ent-16beta,17-Dihydroxy-19-kauranoic acid3301-61-9  PDF
CFN98989ent-16beta,17-Isopropylidenedioxykaurane58493-71-3  n/a
CFN98888Euscaphic acid53155-25-2  PDF
CFN980952,3-O-Isopropylidenyl euscaphic acid220880-90-0  PDF
CFN980297-Oxo-beta-sitosterol2034-74-4  PDF
CFN99916Beta-Sitosterol83-46-5  PDF
CFN97326Stigmasterol83-48-7  PDF
CFN971147alpha-Hydroxystigmasterol64998-19-2  n/a
CFN98000Stigmasterol glucoside19716-26-8  PDF
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