Natural Products
Siegesbeckia pubescens Makino
Siegesbeckia pubescens (S. pubescens) was widely used to alleviate symptoms of osteoarthritis (OA) in traditional medicine.
Three new ent-kaurane-type diterpenoids, siegesbeckioside, siegesbeckiol and siegesbeckic acid, were isolated together with five known diterpenes from Siegesbeckia pubescens (Xi-Xian). On the basis of chemical and spectral evidences, their structures were elucidated as ent-16β,17,18-trihydroxy-kauran 18-O-β-d-glucopyranoside, ent-kauran-2α,16β,17-triol, ent-16α,17,18-dihydroxy-kauran-19-oic acid, ent-kauran-16β,17,18-triol, ent-16β,17-dihydroxy-kauran-19-oic acid, ent-16α,17-hydroxy-kauran-19-oic acid, grandifloric acid and kirenol, respectively.
A novel HPLC method was developed for the simultaneous quantification of seven major diterpenoids of two types, including ent-pimarane type: Kirenol, Hythiemoside B, Darutigenol, and ent-kaurane type: ent-16β,17,18-trihydroxy-kauran-19-oic acid, ent-17,18-dihydroxy-kauran-19-oic acid, ent-16β,17-dihydroxy-kauran-19-oic acid, 16α-hydro-ent-kauran-17,19-dioic acid in the aerial parts of Siegesbeckia pubescens.
A novel HPLC method was developed for the simultaneous quantification of seven major diterpenoids of two types, including ent-pimarane type: Kirenol, Hythiemoside B, Darutigenol, and ent-kaurane type: ent-16β,17,18-trihydroxy-kauran-19-oic acid, ent-17,18-dihydroxy-kauran-19-oic acid, ent-16β,17-dihydroxy-kauran-19-oic acid, 16α-hydro-ent-kauran-17,19-dioic acid in the aerial parts of Siegesbeckia pubescens.
Research products of Siegesbeckia pubescens Makino
Catalog | Product Name | CAS Number | Manual |
---|---|---|---|
CFN97004 | Darutoside | 59219-65-7 | |
CFN97006 | Darutigenol | 5940-00-1 | |
CFN98867 | Kirenol | 52659-56-0 | |
CFN98424 | ent-16beta,17-Dihydroxy-19-kauranoic acid | 3301-61-9 | |
CFN98989 | ent-16beta,17-Isopropylidenedioxykaurane | 58493-71-3 | n/a |
CFN98888 | Euscaphic acid | 53155-25-2 | |
CFN98095 | 2,3-O-Isopropylidenyl euscaphic acid | 220880-90-0 | |
CFN98029 | 7-Oxo-beta-sitosterol | 2034-74-4 | |
CFN99916 | Beta-Sitosterol | 83-46-5 | |
CFN97326 | Stigmasterol | 83-48-7 | |
CFN97114 | 7alpha-Hydroxystigmasterol | 64998-19-2 | n/a |
CFN98000 | Stigmasterol glucoside | 19716-26-8 |
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