Sophora tonkinensis is a herb used in traditional Chinese medicine. Sofalcone is an oral gastrointestinal medication and a synthetic derivative of sophoradin, an isoprenyl chalcone found in S. tonkinensis.
A new matrine-type alkaloid, (-)-14 beta-hydroxyoxymatrine (1), was isolated from the roots and rhizomes of Sophora tonkinensis Gapnep. (Leguminosae), together with five known matrine-type alkaloids, (-)-14 beta-hydroxymatrine (2), (+)-oxymatrine (3), (+)-matrine (4), (+)-sophoranol (5), and (-)-5 alpha-hydroxysophocarpine ( 6), as well as with two known cytisine-type alkaloids, (-)-cytisine (7) and (-)- N-methylcytisine (8). Their structures were elucidated by spectroscopic methods. Compounds 1, 5 and 7 showed potent anti-HBV activity with an inhibitory potency against HBsAg secretion of 22.6 %, 31.1 % and 33.2 %, and against HBeAg secretion of 30.4 %, 26.3 % and 27.8 %, respectively.
Catalog | Product Name | CAS Number | Manual |
---|---|---|---|
CFN98835 | Matrine | 519-02-8 | |
CFN99805 | Oxymatrine | 16837-52-8 | |
CFN99776 | N-Methylcytisine | 486-86-2 | |
CFN99513 | Cytisine | 485-35-8 | |
CFN92067 | Anagyrine | 486-89-5 | |
CFN97160 | Trifolirhizin | 6807-83-6 | |
CFN99746 | Maackiain | 19908-48-6 | |
CFN99156 | Liquiritigenin | 578-86-9 | |
CFN97326 | Stigmasterol | 83-48-7 | |
CFN98913 | Lupeol | 545-47-1 | |
CFN99057 | Lupeol caffeate | 103917-26-6 | |
CFN99962 | Formononetin | 485-72-3 | |
CFN98681 | Genistein | 446-72-0 | |
CFN99257 | 2'-Hydroxygenistein | 1156-78-1 | |
CFN97720 | Homopterocarpin | 606-91-7 |
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