• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    4-O-Methylbutein
    4-O-Methylbutein
    Information
    CAS No. 13323-67-6 Price
    Catalog No.CFN96387Purity>=98%
    Molecular Weight286.3Type of CompoundFlavonoids
    FormulaC16H14O5Physical DescriptionYellow powder
    Download     COA    MSDSSimilar structuralComparison
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Almansora University (Egypt)
  • Medizinische Universit?t Wien (Austria)
  • University of Vienna (Austria)
  • Biotech R&D Institute (USA)
  • Northeast Normal University Chan... (China)
  • University of Lodz (Poland)
  • Universidade Federal de Santa Ca... (Brazil)
  • University of Oslo (Norway)
  • The Australian National University (Australia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Nicolaus Copernicus Uniwersity (Poland)
  • More...
  • Package
    Featured Products
    Salviolone

    Catalog No: CFN92163
    CAS No: 119400-86-1
    Price: $595/5mg
    Echinacoside

    Catalog No: CFN98105
    CAS No: 82854-37-3
    Price: $90/20mg
    Neochamaejasmine A

    Catalog No: CFN92151
    CAS No: 90411-13-5
    Price: $418/5mg
    1,5-Dicaffeoylquinic acid

    Catalog No: CFN99123
    CAS No: 30964-13-7
    Price: $228/20mg
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $298/10mg
    4-O-Methylbutein Description
    Source: The flower heads of Dahlia tenuicaulis Sorensen.
    Biological Activity or Inhibitors: 1. 4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of HO-1 has proven to be a useful tool for fighting inflammation,suggests that 4-O-methylbutein may have anti-inflammation activity.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    4-O-Methylbutein References Information
    Citation [1]

    Phytochemistry,1975,14(7):1621-3.

    Flavonoids and polyacetylenes in Dahlia tenuicaulis[Reference: WebLink]
    5,7,4′-Trimethoxyflavanone,5-hydroxy-7,4′-dimethoxyflavanone,2′-hydroxy-4,4′,6′-trimeth-oxychalcone, and a new naturally occurring compound, 5,7,4′-trimethoxyflavan-4-ol have been isolated from the leaves of Dahlia tenuicaulis Sorensen. Two chalcones, 4,2′,4′-trihydroxychalcone and 3,2′,4′-trihydroxy-4-methoxychalcone(4-O-Methylbutein), and 5-hydroxy-7,4′-dimethoxyflavanone have been isolated from the flower heads. Minute amounts of the polyacetylene 1,3-diacetoxy-tetradeca-4,6-diene-8,10,12-triyne have been found in both leaves and flower heads, whereas 1-acetoxy-tetradeca-4,6-diene-8,10,12-triyne was present only in the flower heads.
    Citation [2]

    Free Radic Biol Med. 2015 Jan;78:135-46.

    Identification of heme oxygenase-1 stimulators by a convenient ELISA-based bilirubin quantification assay.[Pubmed: 25462643 ]
    The upregulation of heme oxygenase-1 (HO-1) has proven to be a useful tool for fighting inflammation. In order to identify new HO-1 inducers, an efficient screening method was developed which can provide new lead structures for drug research. We designed a simple ELISA-based HO-1 enzyme activity assay, which allows for the screening of 12 compounds in parallel in the setting of a 96-well plate. The activity of known HO-1 inducers was confirmed, while the chalcones cardamonin, flavokawain A, calythropsin, 2',3,4'-trihydroxy-4-methoxychalcone (4-O-Methylbutein,THMC), and 2',4'-dihydroxy-3,4-dimethoxychalcone (DHDMC) were identified as new potent HO-1 inducers. The highest inductive power after 6h incubation was found at 10 uM for DHDMC (6.1-fold), carnosol (3.9-fold), butein (3.1-fold), THMC (2.9-fold), and zerumbone (2.5-fold). Moreover, the time dependence of HO-1 protein production for DHDMC was compared to its enzyme activity, which was further evaluated in the presence of lipopolysaccharide and the specific HO-1 inhibitor tin protoporphyrin IX. Taken together, we developed a convenient and highly sensitive ELISA-based HO-1 enzyme activity assay, allowing the identification and characterization of molecules potentially useful for the treatment of inflammatory and autoimmune diseases.