|Source:||The roots of Citrus sinensis.|
|Biological Activity or Inhibitors:|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.6195 mL||18.0976 mL||36.1952 mL||72.3903 mL||90.4879 mL|
|5 mM||0.7239 mL||3.6195 mL||7.239 mL||14.4781 mL||18.0976 mL|
|10 mM||0.362 mL||1.8098 mL||3.6195 mL||7.239 mL||9.0488 mL|
|50 mM||0.0724 mL||0.362 mL||0.7239 mL||1.4478 mL||1.8098 mL|
|100 mM||0.0362 mL||0.181 mL||0.362 mL||0.7239 mL||0.9049 mL|
Phytother Res. 2007 Apr;21(4):386-90.
|Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.[Pubmed: 17236173 ]|
|Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and Thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.|
Zhong Yao Cai. 2013 May;36(5):744-6.
|Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum.[Pubmed: 24218965]|
|To study the chemical constituents from ethyl acetate extract of Micromelum falcatum. METHODS: The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS). RESULTS: Ten compounds were isolated and identified as micropubescin (1), phebalosin (2), scopoletin (3), citrubuntin (4), Thamnosmonin (5), hopeyhopin (6), arnottinin (7), casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10). CONCLUSION: Compounds 1 - 10 are obtained from this plant for the first time.|