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Natural Products
Ajuga ciliata Bunge.

Ajuga ciliata Bunge, Herbs perennial. Stems erect, 25-40 cm tall, purplish red or greenish red. Petiole 1 cm or more, sometimes purple-red, amplexicaul, gray pilose or ciliate only on margin; leaf blade ovate-elliptic to narrowly elliptic.

Three new (1-3) and three known (4-6) neo-clerodane diterpenes have been isolated from the whole plants of Ajuga ciliata Bunge. The structures of the new compounds were elucidated as (12S)-1β,6α,19-triacetoxy-18-chloro-4α,12-dihydroxy-neo-clerod-13-en-15,16-olide (1), (12S,2'S)-12,19-diacetoxy-18-chloro-4α,6α-dihydroxy-1β-(2-methylbutanoyloxy)-neo-clerod-13-en-15,16-olide (2), and (12S)-6α,18,19-triacetoxy-4α,12-dihydroxy-1β-tigloyloxy-neo-clerod-13-en-15,16-olide (3), on the basis of spectroscopic data analysis. All the diterpenes were evaluated for the neuroprotective effects against MPP(+)-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells and compounds 2-5 exhibited moderate neuroprotective effects.

Ajuga ciliata Bunge.
Research products of Ajuga ciliata Bunge.
Catalog Product Name CAS Number Manual
CFN97439Dihydroajugapitin87480-84-0  n/a
CFN92751Ajugamarin F4122587-84-2  n/a
CFN92752Ajugacumbin A124961-66-6  PDF
CFN92753Ajugamarin H1122616-88-0  n/a
CFN92754Ajugamarin G1122587-83-1  n/a
CFN92755Ajuganipponin A936323-13-6  n/a
CFN92756Ajugatakasin A197723-20-9  n/a
CFN92757Ajugamarin L2 (Ajugacumbin B)124961-67-7  n/a
CFN92758Ajugapantin A121449-67-0  n/a
CFN92759Ajugamarin chlorohydrin85447-27-4  n/a
CFN92760Ajugalide D853247-65-1  n/a
CFN90616Ajugasterone C23044-80-6  PDF
CFN91959Ajugalide C853247-64-0  n/a
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