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4-Hydroxybenzylamine
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Product Name 4-Hydroxybenzylamine
Price:
CAS No.: 696-60-6
Catalog No.: CFN00081
Molecular Formula: C7H9NO
Molecular Weight: 123.15 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The herbs of Reseda media
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 4-Hydroxybenzaldehyde derivatives are inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), 4-Hydroxybenzylamine also shows the competitive inhibition on GABA-T with respect to GABA.
Targets: GABA Receptor
In vitro:
Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.[Pubmed: 16290145 ]
4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).
METHODS AND RESULTS:
Investigation of structure-activity relation revealed that a carbonyl group or an amino group as well as a hydroxy group at the para position of the benzene ring are important for both enzymes' inhibition. HBA was shown to give competitive inhibition of GABA-T with respect to alpha-ketoglutarate and competitive inhibition of SSADH. 4-Hydroxybenzylamine (HBM) also showed the competitive inhibition on GABA-T with respect to GABA.
CONCLUSIONS:
In conclusion, the inhibitory effects of HBA and HBM on both enzymes could result from the similarity between both molecules and the two enzymes' substrates in structure, as well as the conjugative effect of the benzene ring. This suggested that the presence of the benzene ring may be accepted by the active site of both enzymes, HBA and HBM may be considered as lead compounds to design novel GABA-T inhibitors.
4-Hydroxybenzylamine Description
Source: The herbs of Reseda media
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 8.1202 mL 40.6009 mL 81.2018 mL 162.4036 mL 203.0045 mL
5 mM 1.624 mL 8.1202 mL 16.2404 mL 32.4807 mL 40.6009 mL
10 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
50 mM 0.1624 mL 0.812 mL 1.624 mL 3.2481 mL 4.0601 mL
100 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1984,23(4):895-896.
N5-(4-hydroxybenzyl) glutamine, 4-hydroxybenzylamine and 4-hydroxybenzylglucosinolate in Sinapis species[Reference: WebLink]

METHODS AND RESULTS:
N5-(4-hydroxybenzyl) glutamine has been isolated from Sinapis alba L. and S. arvensis L. The identification is based on data obtained by HPLC, paper chromatography, high voltage electrophoresis, UV and NMR spectroscopy of the amide and its degradation products. The amide occurs together with 4-Hydroxybenzylamine and sinalbin in both seeds and seedlings of the Sinapis species.
CONCLUSIONS:
This co-occurrence is briefly discussed in relation to chemotaxonomy, glucosinolate catabolism and amine metabolism.
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