7-O-Methylaloeresin A | CAS:329361-25-3

7-O-Methylaloeresin A

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Description:

7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE. 7-O-Methylaloeresin A exhibits good activity against multiple drug resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255) with MIC values of 0.72 and 0.18 mm, respectively.

Targets:

BACE

In vitro:

Phytother Res. 2011 Dec;25(12):1756-60.

In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana Reynolds.[Pubmed: 21452374]

Anthrone (aloin) and chromone (7-O-Methylaloeresin A).
METHODS AND RESULTS:
The latex and its two constituents were assessed for their possible antimicrobial activities against 23 bacterial and four fungal strains using the disc diffusion method and their antioxidant activity by two complementary test systems, namely 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2-deoxyribose degradation assay methods. The isolated compounds showed promising results against various pathogenic bacterial and fungal strains in comparison with standard drugs. Moreover, 7-O-Methylaloeresin A exhibited good activity against multiple drug resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255) with MIC values of 0.72 and 0.18 mm, respectively. Among the fungal strains tested, Candida albicans (ATCC 10231) was the most susceptible organism to the latex and the two isolated compounds. The latex and isolated compounds also showed significant activities on both antioxidant assays with the highest activity being observed for 7-O-Methylaloeresin A, which gave IC(50) values of 0.026 mm and 0.021 mm for DPPH and 2-deoxyribose degradation assay, respectively.
CONCLUSIONS:
These findings support the traditional uses of the plant for the treatment of various infectious and inflammatory diseases.

7-O-Methylaloeresin A Description

Source:	The herbs of Aloe arborescens Mill.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Yao Xue Xue Bao. 2006 Oct;41(10):1000-3.

Active constituents from Aloe arborescens as BACE inhibitors.[Pubmed: 17184120]

To seek for new components as BACE inhibitors from Aloe arborescens.
METHODS AND RESULTS:
The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-Methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
CONCLUSIONS:
Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

Product Name	7-O-Methylaloeresin A
Price:	$318 / 10mg
CAS No.:	329361-25-3
Catalog No.:	CFN90716
Molecular Formula:	C₂₉H₃₀O₁₁
Molecular Weight:	554.54 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Aloe arborescens Mill.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Inhibitors Compound Library Antibacterial Compound Library Flavonoids Compound Library BACE Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8033 mL	9.0165 mL	18.033 mL	36.0659 mL	45.0824 mL
5 mM	0.3607 mL	1.8033 mL	3.6066 mL	7.2132 mL	9.0165 mL
10 mM	0.1803 mL	0.9016 mL	1.8033 mL	3.6066 mL	4.5082 mL
50 mM	0.0361 mL	0.1803 mL	0.3607 mL	0.7213 mL	0.9016 mL
100 mM	0.018 mL	0.0902 mL	0.1803 mL	0.3607 mL	0.4508 mL

CFN96198	8-Methyleugenitol	41682-21-7	220.2	C₁₂H₁₂O₄
CFN97544	5,7-Dihydroxy-2-isopropylchromone	96552-59-9	220.2	C₁₂H₁₂O₄
CFN89218	8-Glucosyl-5,7-dihydroxy-2-(1-methylpropyl)chromone	188818-27-1	396.39	C₁₉H₂₄O₉
CFN97171	6-Acetyl-2,2-dimethylchroman-4-one	68799-41-7	218.3	C₁₃H₁₄O₃
CFN96894	2,5-Dimethylchroman-4-one	69687-87-2	176.21	C₁₁H₁₂O₂
CFN89130	Altechromone A	38412-47-4	190.19	C₁₁H₁₀O₃
CFN98359	Cassiachromone	28955-30-8	232.2	C₁₃H₁₂O₄
CFN96962	dl-Aloesol	104871-04-7	234.25	C₁₃H₁₄O₄
CFN91659	Aloesin	30861-27-9	394.37	C₁₉H₂₂O₉
CFN90716	7-O-Methylaloeresin A	329361-25-3	554.54	C₂₉H₃₀O₁₁