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Alizarin 2-methyl ether
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Alizarin 2-methyl ether
Price:
CAS No.: 6003-11-8
Catalog No.: CFN92569
Molecular Formula: C15H10O4
Molecular Weight: 254.2 g/mol
Purity: >=98%
Type of Compound: Anthraquinones
Physical Desc.: Red cryst.
Source: The roots of Rubia cordifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Alizarin 2-methyl ether enhances adipocyte differentiation by up to 131%, it could be beneficial in the treatment of diabetes.
In vitro:
Nat Prod Res. 2012;26(18):1750-4.
Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells.[Pubmed: 22008000]
To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining.
METHODS AND RESULTS:
Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), Alizarin 2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, Alizarin 2-methyl ether (2) showed the strongest enhancing activity, followed by rubiadin-1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 µM, Alizarin 2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells).
CONCLUSIONS:
Thus, these compounds could be beneficial in the treatment of diabetes.
Alizarin 2-methyl ether Description
Source: The roots of Rubia cordifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry, 1986 , 25 (5) :1123-6.
Anthraquinones in callus cultures of Cinchona pubescens[Reference: WebLink]

METHODS AND RESULTS:
From callus cultures of Cinchona pubescens seven known anthraquinones, Alizarin 2-methyl ether, anthragallol-1,2-dimethylether, purpurin, purpurin-1-methylether, 1-hydroxy-2-hydroxymethylanthraquinone, 2-hydroxy-1,3,4-trimethoxyanthraquinone and 2,5-(or 3,5-)dihydroxy-1,3,4-(or -1,2,4-)trimethoxyanthraquinone, and five new anthraquinones, 2-hydroxy-1,3,4,6-(or -1,3,4,7-)tetramethoxyanthraquinone, 1,6-(or 1,7-)dihydroxy-2-methylanthraquinone, 5-hydroxy-purpurin-1-methylether, 4,6-(or 4,7)-dihydroxy-2,7-(or -2,6-)dimethoxyanthraquinone and 6,7-dihydroxy-1-methoxy-2-methylanthraquinone have been isolated.
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