Anemoside A3 | CAS:129724-84-1 | Manufacturer ChemFaces

Anemoside A3

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Size /Price /Stock	10 mM * 1 mL in DMSO / $33.5 / In-stock
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Description:

Anemoside A3 is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases. Anemoside A3 also produces relaxation in rat renal arteries through multiple mechanisms.

Targets:

NMDAR | Calcium Channel | Potassium Channel

In vitro:

Neuropsychopharmacology. 2015 Jul;40(8):1877-87.

Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection.[Pubmed: 25649278]

Compounds that have the ability to both strengthen synaptic function and facilitate neuroprotection are valuable cognitive enhancers that may improve health and quality of life, as well as retard age-related cognitive deterioration. Medicinal plants are an abundant source of potential cognitive enhancers.
METHODS AND RESULTS:
Here we report that Anemoside A3 (AA3) isolated from Pulsatilla chinensis modulates synaptic connectivity in circuits central to memory enhancement. Anemoside A3 specifically modulates the function of AMPA-type glutamate receptors (AMPARs) by increasing serine phosphorylation within the GluA1 subunit, which is a modification required for the trafficking of GluA1-containing AMPARs to synapses. Furthermore, Anemoside A3 administration activates several synaptic signaling molecules and increases protein expressions of the neurotrophin brain-derived neurotrophic factor and monoamine neurotransmitters in the mouse hippocampus. In addition to acting through AMPARs, Anemoside A3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. These findings collectively suggest that AA3 possesses a unique ability to modulate the functions of both AMPARs and NMDARs. Concordantly, behavioral studies indicate that AA3 not only facilitates hippocampal long-term potentiation but also enhances spatial reference memory formation in mice.
CONCLUSIONS:
These multifaceted roles suggest that Anemoside A3 is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases.

Planta Med. 2003 Feb;69(2):171-4.

Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation.[Pubmed: 12624827]

METHODS AND RESULTS:
Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A 3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A 3, at dosages ranging from 0.1, 1 and 10 microg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

Anemoside A3 Description

Source:	The roots of Pulsatilla chinensis.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2010 Nov;76(16):1814-9.

Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition.[Pubmed: 20506075]

Anemoside A3, a lupane-type triterpenoid saponin, exists in the roots of Pulsatilla chinensis, but its pharmacological properties are largely unknown.
METHODS AND RESULTS:
The present study aimed to investigate the mechanisms underlying Anemoside A3 induced relaxation in rat renal arteries. Changes of isometric force were determined on arteries with a myograph. Anemoside A3 caused concentration-dependent relaxation in precontracted aortas, mesenteric, left coronary, and renal arteries. Removal of endothelium or treatment with charybdotoxin plus apamin slightly but significantly attenuated the relaxation in renal arteries. TEA(+) inhibited the relaxation caused by Anemoside A3 in renal arteries with and without endothelium while glibenclamide, BaCl(2), or capsaicin had no effect on it. Anemoside A3 produced less relaxation in rings contracted by 60 mM KCl compared with rings contracted by receptor-dependent constrictors. It further inhibited contractions induced by Ca(2+) influx through nifedipine-sensitive voltage-gated Ca(2+) channels, nifedipine-insensitive receptor-operated Ca(2+) channels, and by intracellular Ca(2+) release. Pretreatment with nifedipine attenuated Anemoside A3-induced relaxation.
CONCLUSIONS:
Taken together, the present results indicate that Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. The release of CTX/apamin-sensitive endothelium-derived hyperpolarizing factor, stimulation of TEA(+)-sensitive K(+) channel, and inhibition of Ca(2+) influx jointly contribute to the relaxation.

Product Name	Anemoside A3
Price:	$80 / 20mg
CAS No.:	129724-84-1
Catalog No.:	CFN90182
Molecular Formula:	C₄₁H₆₆O₁₂
Molecular Weight:	750.96 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Pulsatilla chinensis.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-Parkinson Compound Library Triterpenoids Compound Library Potassium Channel Inhibitor Library NMDAR Inhibitor Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3316 mL	6.6581 mL	13.3163 mL	26.6326 mL	33.2907 mL
5 mM	0.2663 mL	1.3316 mL	2.6633 mL	5.3265 mL	6.6581 mL
10 mM	0.1332 mL	0.6658 mL	1.3316 mL	2.6633 mL	3.3291 mL
50 mM	0.0266 mL	0.1332 mL	0.2663 mL	0.5327 mL	0.6658 mL
100 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.2663 mL	0.3329 mL

CFN99786	Anemoside B4	129741-57-7	1221.38	C₅₉H₉₆O₂₆
CFN80291	Pulchinenoside E	366814-43-9	1383.534	C₆₅H₁₀₆O₃₁
CFN96240	3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid	262272-76-4	530.7	C₃₁H₄₆O₇
CFN89222	3alpha-Acetoxy-20(29)-lupene-23,28-dioic acid	83725-41-1	528.73	C₃₂H₄₈O₆
CFN96223	Acantrifoic acid A	654663-85-1	544.7	C₃₂H₄₈O₇
CFN70298	Bacosine	198014-94-7	456.7	C₃₀H₄₈O₃
CFN99759	Betulinaldehyde	13159-28-9	440.70	C₃₀H₄₈O₂
CFN98706	Betulinic acid	472-15-1	456.7	C₃₀H₄₈O₃
CFN91073	Betulinic acid methyl ester	2259-06-5	470.7	C₃₁H₅₀O₃
CFN89164	Pyracrenic acid	80832-44-6	618.85	C₃₉H₅₄O₆