| Structure Identification: |
| Zhong Yao Cai. 2014 Feb;37(2):266-9. | | Chemical constituents from Dichotella gemmacea.[Pubmed: 25095349] | To study the chemical constituents from Dichotella gemmacea.
METHODS AND RESULTS:
Chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography. The structures of the isolated compounds were elucidated through spectroscopic analysis.
Eight compounds were identified as fragilide J(I), junceelldide D(II), junceellin A (IlI), juncin P(IV), dichotellides A (V), Cerevisterol (VI), 1,2-diphenyldiselane (VII) and 5H-pyrido[4,3-b] indole (VIII).
CONCLUSIONS:
Compounds VI, VII and VIII are isolated from Dichotella gemmacea for the first time. | | Bioorg. Med. Chem. Lett., 2015, 25(22):5078-82. | | Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells.[Pubmed: 26481911] |
METHODS AND RESULTS:
One new meroterpenoid, named hericenone K (11), along with 10 known compounds (1-10), ergosterol peroxide (1), Cerevisterol (2), 3β,5α,9α-trihydroxy-ergosta-7,22-dien-6-one (3), inoterpene A (4), astradoric acid C (5), betulin (6), oleanolic acid (7), ursolic acid (8), hemisceramide (9), and 3,4-dihydro-5-methoxy-2-methyl-2-(4'-methyl-2'-oxo-3'-pentenyl)-9(7H)-oxo-2H-furo[3,4-h]benzopyran (10), was isolated from the fruiting bodies of the mushroom Hericium erinaceus. Their structures were characterized on the basis of spectroscopic methods, as well as through comparison with previously reported data.
CONCLUSIONS:
Compounds 3-6, 8, and 9 were isolated from Hericium species for the first time. Compounds 10 and 11 was suggested to be racemic by the CD spectrum data and specific rotations, which ware resolved by chiral HPLC into respective enantiomers. Compounds 1-3, (±)-10, (-)-10 and (+)-10 in the presence of NGF (20 ng/mL) exerted a significant increase in neurite-bearing cells. |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
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ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
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