| In vitro: |
| Chinese Journal of Microecology, 2015 , 27 (12) :1392-6. | | The triterpenoids from medicinal macrofungi Ganodermalucidum.[Reference: WebLink] | To study the bioactivity and structure of the triterpenoids in Ganodermalucidum(Polyporaceae).
METHODS AND RESULTS:
The ethanolic extracts of Ganodermalucidum was diluted with water and extracted with CHCl_3.The CHCl_3 extract was subjected to silica gel column chromatography and HPLC successively.The structures of isolated compounds were identified by using various spectroscopic techiques,including UV,ESI-MS,HRESI-MS,~1H-NMR,~(13)C-NMR and 2D-NMR.Theα-Glucosidase inhibitory activity of the extracted compounds were evaluated in vitro.7lanostane triterpenoids(Compound 1to 7)were isolated from the fruiting body of Ganodermalucidum,which were identified as Ganoderic acid X1(Compound 1),Ganoderic acid C(Compound 2),Deacetyl ganoderic acid F(Compound 3),Ganoderic B(Compound 4),Lucienic acid A(Compound 5),7-hydroxy-3,11,15-trioxo-lanosta-8-en-24→20sLactone(Compound 6)and Methyl lucidenate D2(Compound 7).An in vitro bioassay showed that the compounds 1and 6 have certainα-Glucosidase inhibitory activities.
CONCLUSIONS:
Lanostane triterpenoids are the major ingredients of Ganodermalucidum.Ganoderic acid X1 is a new triterpenoid not reported before. These chemical ingredients have certain bioactivities. |
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