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Doronenine
Doronenine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Doronenine
Price:
CAS No.: 74217-57-5
Catalog No.: CFN00354
Molecular Formula: C18H25NO5
Molecular Weight: 335.40 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Senecio doronicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
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  • University of Sao Paulo (Brazil)
  • Warszawski Uniwersytet Medyczny (Poland)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Doronenine shows moderate cytotoxicity on cancerous U-937 cells.
In vitro:
J Ethnopharmacol. 2011 Dec 8;138(3):748-55.
In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf.[Pubmed: 22041105]

METHODS AND RESULTS:
A bioassay guided fractionation of the ethanol extract led to the isolation of two pure compounds, namely madurensine and Doronenine. Madurensine and Doronenine showed moderate cytotoxicity on cancerous U-937 cells (IC(50) values: 47.97 and 29.57 M respectively).
CONCLUSIONS:
The crude extract treated U-937 cells showed definite signs of cell death during light microscopic investigation, while little apoptosis (10-20%) and necrosis (<2%) were detected in cells treated with the extract or madurensine.
Doronenine Description
Source: The herbs of Senecio doronicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9815 mL 14.9076 mL 29.8151 mL 59.6303 mL 74.5379 mL
5 mM 0.5963 mL 2.9815 mL 5.963 mL 11.9261 mL 14.9076 mL
10 mM 0.2982 mL 1.4908 mL 2.9815 mL 5.963 mL 7.4538 mL
50 mM 0.0596 mL 0.2982 mL 0.5963 mL 1.1926 mL 1.4908 mL
100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.5963 mL 0.7454 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN00362Crosemperine30785-56-9367.44C19H29NO6
CFN00364Crotalarine53937-97-6353.41C18H27NO6
CFN00369Erucifoline40158-95-0349.38C18H23NO6
CFN00453Erucifolin N-oxide123864-94-8365.4C18H23NO7
CFN00375Jacobine6870-67-3351.40C18H25NO6
CFN00461Jacobine N-oxide38710-25-7367.4C18H25NO7
CFN00380Madurensine26126-78-3351.40C18H25NO6
CFN00382Spiranine77156-23-1469.53C23H35NO9
CFN00385Monocrotaline N-oxide35337-98-5341.36C16H23NO7
CFN00386Spectabiline520-55-8367.40C18H25NO7
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