Science | Nature | Cell | View More
Natural Products
Ganoderiol A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ganoderiol A
Price:
CAS No.: 106518-61-0
Catalog No.: CFN80461
Molecular Formula: C30H50O4
Molecular Weight: 474.37 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Oil
Source: The fruit body of Ganoderma lucidum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade Federal de Goias (... (Brazil)
  • Weizmann Institute of Science (Israel)
  • Kyushu University (Japan)
  • University of Auckland (New Zealand)
  • University of Bordeaux (France)
  • University of Helsinki (Finland)
  • Universidad Miguel Hernández (Spain)
  • Johannes Gutenberg University M... (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Griffith University (Australia)
  • Universita' Degli Studi Di Cagl... (Italy)
  • More...
Package
Featured Products
Acanthoside B

Catalog No: CFN97220
CAS No: 7374-79-0
Price: $268/20mg
Caffeic acid

Catalog No: CFN99190
CAS No: 331-39-5
Price: $30/20mg
Carlinoside

Catalog No: CFN90720
CAS No: 59952-97-5
Price: $318/5mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
(+)-Borneol

Catalog No: CFN70111
CAS No: 464-43-7
Price: $30/20mg
Schizandrin B

Catalog No: CFN99923
CAS No: 61281-37-6
Price: $50/20mg
Rhynchophylline

Catalog No: CFN98131
CAS No: 76-66-4
Price: $98/20mg
Kaempferol-7-O-D-glucopyranoside

Catalog No: CFN90150
CAS No: 16290-07-6
Price: $268/5mg
2,3,2'',3''-Tetrahydroochnaflavone

Catalog No: CFN97157
CAS No: 678138-59-5
Price: $ /
Cosmosiin

Catalog No: CFN98981
CAS No: 578-74-5
Price: $80/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ganoderiol A suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-Paxillin cascade pathway.
Targets: Src
In vitro:
PLoS One. 2013 Oct 29;8(10):e76620.
Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.[Pubmed: 24204647 ]
Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties.
METHODS AND RESULTS:
Herein, GAEE, G. lucidum extract mainly contains Ganoderiol A (GA), dihydrogenated GA and GA isomer, was shown to inhibit the abilities of adhesion and migration, while have a slight influence on that of invasion in highly metastatic breast cancer MDA-MB-231 cells at non-toxic doses. Further investigation revealed that GAEE decreased the active forms of focal adhesion kinase (FAK) and disrupted the interaction between FAK and SRC, which lead to deactivating of paxillin. Moreover, GAEE treatment downregulated the expressions of RhoA, Rac1, and Cdc42, and decreased the interaction between neural Wiskott-Aldrich Syndrome protein (N-WASP) and Cdc42, which impair cell migration and actin assembly.
CONCLUSIONS:
To our knowledge, this is the first report to show that G.lucidum triterpenoids could suppress cell migration and adhesion through FAK-SRC-paxillin signaling pathway. Our study also suggests that GAEE may be a potential agent for treatment of breast cancer.
Ganoderiol A Description
Source: The fruit body of Ganoderma lucidum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Oblongaroside B

Catalog No: CFN95543
CAS No: 1000889-11-1
Price: $318/10mg
Campneoside II

Catalog No: CFN95498
CAS No: 95587-86-3
Price: $318/10mg
5,6,7,3',4'-Pentamethoxyflavanone

Catalog No: CFN95394
CAS No: 104193-93-3
Price: $318/5mg
3',3'''-Binaringenin

Catalog No: CFN95558
CAS No: 145399-99-1
Price: $413/5mg
Silychristin B

Catalog No: CFN95160
CAS No: 879325-58-3
Price: $318/5mg
Diosmin Impurity 8

Catalog No: CFN95309
CAS No: 28719-21-3
Price: $318/10mg
Methyl 2-hydroxy-3,4-dimethoxybenz...

Catalog No: CFN95383
CAS No: 6395-23-9
Price: $268/5mg
Fragransin B1

Catalog No: CFN95443
CAS No: 112516-03-7
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1081 mL 10.5403 mL 21.0806 mL 42.1612 mL 52.7015 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL 8.4322 mL 10.5403 mL
10 mM 0.2108 mL 1.054 mL 2.1081 mL 4.2161 mL 5.2701 mL
50 mM 0.0422 mL 0.2108 mL 0.4216 mL 0.8432 mL 1.054 mL
100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.4216 mL 0.527 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Journal of the Agricultural Chemical Society of Japan, 1986, 50(11):2887-28
Ganoderiol A and B, New Triterpenoids from the Fungus Ganoderma lucidum (Reishi)[Reference: WebLink]

METHODS AND RESULTS:
Two new lanostane-type triterpenoids, Ganoderiol A (1) and ganoderiol B (2) were isolated from the fruiting bodies of Ganoderma lucidum, together with known ganodermanontriol (3) and ganodermatriol (4).
CONCLUSIONS:
The compounds were identified as 5α-lanosta-7,9(11)-dien-3β,24,25,26-tetraol (1), 15α,26,27-trihydroxy-5α-lanosta-7,9(11),24-trien-3-one (2), 24,25,26-trihydroxy-5α-lanosta-7,9(11)-dien-3-one (3) and 5α-lanosta-7,9(ll),24-trien-3β,26,27-triol (4), respectively.
Acanthoside B

Catalog No: CFN97220
CAS No: 7374-79-0
Price: $268/20mg
Caffeic acid

Catalog No: CFN99190
CAS No: 331-39-5
Price: $30/20mg
Carlinoside

Catalog No: CFN90720
CAS No: 59952-97-5
Price: $318/5mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
(+)-Borneol

Catalog No: CFN70111
CAS No: 464-43-7
Price: $30/20mg
Schizandrin B

Catalog No: CFN99923
CAS No: 61281-37-6
Price: $50/20mg
Rhynchophylline

Catalog No: CFN98131
CAS No: 76-66-4
Price: $98/20mg
Kaempferol-7-O-D-glucopyranoside

Catalog No: CFN90150
CAS No: 16290-07-6
Price: $268/5mg
2,3,2'',3''-Tetrahydroochnaflavone

Catalog No: CFN97157
CAS No: 678138-59-5
Price: $ /
Cosmosiin

Catalog No: CFN98981
CAS No: 578-74-5
Price: $80/20mg
Tags: buy Ganoderiol A | Ganoderiol A supplier | purchase Ganoderiol A | Ganoderiol A cost | Ganoderiol A manufacturer | order Ganoderiol A | Ganoderiol A distributor