Genkwanol B | CAS:142674-67-7 | Manufacturer ChemFaces

Genkwanol B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Genkwanol B shows potent in vitro antiviral activity against respiratory syncytial virus (RSV).

Targets:

RSV

In vitro:

Chin Med. 2010 Jun 21;5:23.

Antiviral biflavonoids from Radix Wikstroemiae (Liaogewanggen).[Pubmed: 20565950 ]

Radix Wikstroemiae is a common Chinese herbal medicine. The ethyl acetate fraction of the ethanolic extract of W. indica possesses potent in vitro antiviral activity against respiratory syncytial virus (RSV). This study aims to identify the antiviral components of the active fraction.
METHODS AND RESULTS:
The active fraction of the Radix Wikstroemiae extract was isolated with chromatographic methods such as silica gel, Sephadex LH-20 and semi-preparative high performance liquid chromatography (HPLC) columns. The structures of the isolated compounds were determined based on spectroscopic analyses. The in vitro antiviral activity of the compounds against RSV was tested with the cytopathic effect (CPE) reduction assay and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Four biflavonoids, namely neochamaejasmin B, Genkwanol B, Genkwanol C and stelleranol, were isolated and characterized. Genkwanol B, Genkwanol C and stelleranol, which are stereo isomers of spirobiflavonoids, showed potent anti-RSV activity whereas neochamaejasmin B did not.
CONCLUSIONS:
Neochamaejasmin B, Genkwanol B, Genkwanol C and stelleranol were isolated from Radix Wikstroemiae and the complete absolute configurations of five chiral carbons in stelleranol were substantiated for the first time. Furthermore, the anti-RSV activity of Genkwanol B, Genkwanol C and stelleranol was reported for the first time.

Genkwanol B Description

Source:	The roots of Stellera chamaejasme
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Genkwanol B
Price:
CAS No.:	142674-67-7
Catalog No.:	CFN91961
Molecular Formula:	C₃₀H₂₂O₁₁
Molecular Weight:	558.49 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Stellera chamaejasme
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7905 mL	8.9527 mL	17.9054 mL	35.8108 mL	44.7636 mL
5 mM	0.3581 mL	1.7905 mL	3.5811 mL	7.1622 mL	8.9527 mL
10 mM	0.1791 mL	0.8953 mL	1.7905 mL	3.5811 mL	4.4764 mL
50 mM	0.0358 mL	0.1791 mL	0.3581 mL	0.7162 mL	0.8953 mL
100 mM	0.0179 mL	0.0895 mL	0.1791 mL	0.3581 mL	0.4476 mL

CFN91960	Stelleranol	795308-62-2	558.49	C₃₀H₂₂O₁₁
CFN91961	Genkwanol B	142674-67-7	558.49	C₃₀H₂₂O₁₁
CFN91962	Genkwanol C	151283-11-3	558.49	C₃₀H₂₂O₁₁
CFN95553	Mahuannin G	N/A	542.5	C₃₀H₂₂O₁₀
CFN95533	Mahuannin J	N/A	556.5	C₃₀H₂₀O₁₁
CFN95599	Abiesinol B	1190070-89-3	558.5	C₃₀H₂₂O₁₁
CFN95600	Abiesinol A	1190070-88-2	558.5	C₃₀H₂₂O₁₁
CFN95554	Mahuannin B	82796-37-0	544.5	C₃₀H₂₄O₁₀
CFN95579	Ephedrannin A	82001-39-6	556.5	C₃₀H₂₀O₁₁
CFN95598	Epiafzelechin-(2beta-O->7,4beta->8)-ent-epicatechin	135820-73-4	560.5	C₃₀H₂₄O₁₁