Intermedin B | CAS:127214-87-3 | Manufacturer ChemFaces

Intermedin B

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Description:

Intermedin B is a natural product from Alpinia intermedia.

In vivo:

Planta Med. 2017 Jan;83(1-02):151-157.

Intermedin A, a New Labdane Diterpene Isolated from Alpinia intermedia, Prolonged the Survival Time of P-388D1 Tumor-Bearing CDF1 Mice.[Pubmed: 27352383 ]

Eight ethanolic extracts of indigenous Taiwanese plants of the genus Alpinia were tested for tumor cytotoxicity against AGS, Hep G2, HeLa, KB, and HL-60 cells.
METHODS AND RESULTS:
Among the 50 % and 95 % EtOH extracts of eight Alpinia species, the cytotoxic effects of Alpinia intermedia leaves were the strongest. When the leaf extract of A. intermedia was partitioned using n-hexane and aqueous solvents, the n-hexane layer showed a greater cytotoxic effect and could prolong the survival time of P-388D1 tumor-bearing CDF1 mice. Two new labdane diterpene derivatives, intermedin A (1) and Intermedin B (2), and coronarin E (3) were isolated from the n-hexane layer of A. intermedia. Intermedin A induced apoptosis in HL-60 cells at 30 µg/mL and significantly prolonged the survival time of P-388D1 tumor-bearing CDF1 mice by 48.7 % at 20 mg/kg of body weight.
CONCLUSIONS:
We suggest that intermedin A is a major compound of A. intermedia and has a cytotoxic effect on HL-60 and P-388D1 cells.

Intermedin B Description

Source:	The leaves of Alpinia intermedia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Intermedin B
Price:	$288 / 20mg
CAS No.:	127214-87-3
Catalog No.:	CFN89016
Molecular Formula:	C₁₅H₂₂O₂
Molecular Weight:	234.33 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The leaves of Alpinia intermedia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.2675 mL	21.3374 mL	42.6749 mL	85.3497 mL	106.6872 mL
5 mM	0.8535 mL	4.2675 mL	8.535 mL	17.0699 mL	21.3374 mL
10 mM	0.4267 mL	2.1337 mL	4.2675 mL	8.535 mL	10.6687 mL
50 mM	0.0853 mL	0.4267 mL	0.8535 mL	1.707 mL	2.1337 mL
100 mM	0.0427 mL	0.2134 mL	0.4267 mL	0.8535 mL	1.0669 mL

CFN89244	4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one	170380-68-4	220.31	C₁₄H₂₀O₂
CFN97512	9-Oxo-2,7-bisaboladien-15-oic acid	93888-59-6	250.3	C₁₅H₂₂O₃
CFN96371	4-Hydroxy-1,10-secocadin-5-ene-1,10-dione	226904-40-1	252.4	C₁₅H₂₄O₃
CFN91876	Bisabolangelone	30557-81-4	248.32	C₁₅H₂₀O₃
CFN89267	3,4-Seco-3-oxobisabol-10-ene-4,1-olide	1564265-85-5	252.35	C₁₅H₂₄O₃
CFN99670	Catalpalactone	1585-68-8	258.3	C₁₅H₁₄O₄
CFN99782	Fraxinellone	28808-62-0	232.28	C₁₄H₁₆O₃
CFN96832	Dasycarpol	202343-57-5	248.27	C₁₄H₁₆O₄
CFN95485	6-Methoxyfraxinellone	N/A	262.3	C₁₅H₁₈O₄
CFN96453	Vibralactone K	1623786-66-2	210.27	C₁₂H₁₈O₃