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Isorhyncophylline
Isorhyncophylline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isorhyncophylline
Price: $158 / 20mg
CAS No.: 6859-01-4
Catalog No.: CFN92553
Molecular Formula: C22H28N2O4
Molecular Weight: 384.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The vines of Uncaria rhynchopylla.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Isorhyncophylline and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of angiotensin Ⅱ.
Targets: Potassium Channel
In vivo:
Acta Academiae Medicinae Zunyi, 1994 (1) :7-10.
Effects of rhyncophylline and isorhyncophylline on the contractile responses of rat isolated mesenteric arteries and tail artery[Reference: WebLink]

METHODS AND RESULTS:
In rat isolated mesenteric arteries and tail artery, rhyncopylline (Rhy)and Isorhyncophylline(Isorhy)inhibited the increased infusion pressure induced by high K+ (80 mmol/L) and noradrenaline(NA)in a concentration-dependent manner. The potency of both drugs were similar in mesenteric arteries, but in tail artery,the effect of Rhy on high K+ induced infusion pressure increase was weaker than that of Isorhy, and there was a similar trend in the contractile response induced by NA. Both drugs also inhibited the hypertensive effect of angiotensin Ⅱ.
CONCLUSIONS:
The results suggest that in small blood vessels of rat,Rhy and lsorhy can directly inhibit the contractile responses induced by several agonists, but in some arteries, the effect of Rhy may be weaker than that of Isorhy.
Isorhyncophylline Description
Source: The vines of Uncaria rhynchopylla.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6008 mL 13.0039 mL 26.0078 mL 52.0156 mL 65.0195 mL
5 mM 0.5202 mL 2.6008 mL 5.2016 mL 10.4031 mL 13.0039 mL
10 mM 0.2601 mL 1.3004 mL 2.6008 mL 5.2016 mL 6.502 mL
50 mM 0.052 mL 0.2601 mL 0.5202 mL 1.0403 mL 1.3004 mL
100 mM 0.026 mL 0.13 mL 0.2601 mL 0.5202 mL 0.6502 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry.1984;23(2):453–455.
Indole alkaloids from Hannoa klaineana roots.[Reference: WebLink]
1-Methoxycanthin-6-one, rhyncophylline, Isorhyncophylline and four new alkaloids, ethyl-β-carboline-1-propionate, ethyl-β-carboline-2N-oxide-1-propionate, 1-ethyl-β-carboline and 1-ethyl-β-carboline-2N-oxide, were isolated from three different samples of Hannoa klaineana roots.
CFN98132Isorhynchophyllic acid144525-05-3370.44C21H26N2O4
CFN90218Corynoxine6877-32-3384.47C22H28N2O4
CFN92553Isorhyncophylline6859-01-4384.5C22H28N2O4
CFN98131Rhynchophylline76-66-4384.47C22H28N2O4
CFN98154Corynoxeine630-94-4382.45C22H26N2O4
CFN98155Isocorynoxeine51014-29-0382.45C22H26N2O4
CFN92844Dihydrocorynantheine4684-43-9368.5C22H28N2O3
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