Isorhyncophylline | CAS:6859-01-4 | Manufacturer ChemFaces

Isorhyncophylline

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Description:

Isorhyncophylline and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of angiotensin Ⅱ.

Targets:

Potassium Channel

In vivo:

Acta Academiae Medicinae Zunyi, 1994 (1) :7-10.

Effects of rhyncophylline and isorhyncophylline on the contractile responses of rat isolated mesenteric arteries and tail artery[Reference: WebLink]

METHODS AND RESULTS:
In rat isolated mesenteric arteries and tail artery, rhyncopylline (Rhy)and Isorhyncophylline(Isorhy)inhibited the increased infusion pressure induced by high K+ (80 mmol/L) and noradrenaline(NA)in a concentration-dependent manner. The potency of both drugs were similar in mesenteric arteries, but in tail artery,the effect of Rhy on high K+ induced infusion pressure increase was weaker than that of Isorhy, and there was a similar trend in the contractile response induced by NA. Both drugs also inhibited the hypertensive effect of angiotensin Ⅱ.
CONCLUSIONS:
The results suggest that in small blood vessels of rat,Rhy and lsorhy can directly inhibit the contractile responses induced by several agonists, but in some arteries, the effect of Rhy may be weaker than that of Isorhy.

Isorhyncophylline Description

Source:	The vines of Uncaria rhynchopylla.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isorhyncophylline
Price:	$158 / 20mg
CAS No.:	6859-01-4
Catalog No.:	CFN92553
Molecular Formula:	C₂₂H₂₈N₂O₄
Molecular Weight:	384.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The vines of Uncaria rhynchopylla.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihypertensive Compound Library Vasorelaxation Compound Library Alkaloids Compound Library Potassium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6008 mL	13.0039 mL	26.0078 mL	52.0156 mL	65.0195 mL
5 mM	0.5202 mL	2.6008 mL	5.2016 mL	10.4031 mL	13.0039 mL
10 mM	0.2601 mL	1.3004 mL	2.6008 mL	5.2016 mL	6.502 mL
50 mM	0.052 mL	0.2601 mL	0.5202 mL	1.0403 mL	1.3004 mL
100 mM	0.026 mL	0.13 mL	0.2601 mL	0.5202 mL	0.6502 mL

CFN98132	Isorhynchophyllic acid	144525-05-3	370.44	C₂₁H₂₆N₂O₄
CFN90218	Corynoxine	6877-32-3	384.47	C₂₂H₂₈N₂O₄
CFN92553	Isorhyncophylline	6859-01-4	384.5	C₂₂H₂₈N₂O₄
CFN98131	Rhynchophylline	76-66-4	384.47	C₂₂H₂₈N₂O₄
CFN98154	Corynoxeine	630-94-4	382.45	C₂₂H₂₆N₂O₄
CFN98155	Isocorynoxeine	51014-29-0	382.45	C₂₂H₂₆N₂O₄
CFN92844	Dihydrocorynantheine	4684-43-9	368.5	C₂₂H₂₈N₂O₃