Isothymusin | CAS:98755-25-0 | Manufacturer ChemFaces

Isothymusin

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Description:

Isothymusin( MIC= 200 microg/mL) exhibits inhibition activity against Mycobacterium tuberculosis. It ( IC50=7.7 microg/mL ) exhibits antioxidant activity against the radical scavenging ability of DPPH.

Targets:

Antifection

In vitro:

Arch Pharm Res. 2003 Oct;26(10):816-20.

Antimycobacterial and antioxidant flavones from Limnophila geoffrayi.[Pubmed: 14609129]

The chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities.
METHODS AND RESULTS:
Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4'-trimethoxyflavone, 1) and Isothymusin (6,7-dimethoxy-5,8,4'-trihydroxyflavone, 2). Both compounds 1 and Isothymusin exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. Only Isothymusin exhibited antioxidant activity against the radical scavenging ability of DPPH, with the IC50 value of 7.7 microg/mL.
CONCLUSIONS:
The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and Isothymusin did not exhibit mutagenic activity in the Bacillus subtilis recassay.

Isothymusin Description

Source:	The herbs of Limnophila geoffrayi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry. 1998 Mar;47(5):779-82.

An 8-hydroxylated external flavone and its 8-O-glucoside from Becium grandiflorum.[Pubmed: 9542170 ]

METHODS AND RESULTS:
The major vacuolar flavonoid of a greenhouse-grown plant of Becium grandiflorum has been identified as the 8-O-glucoside of Isothymusin (5,8,4'-trihydroxy-6,7-dimethoxyflavone), while the major external flavonoids in the diethyl ether surface wash of the same plant are found to be Isothymusin and cirsimaritin (5,4'-dihydroxy-7,8-dimethoxyflavone).
CONCLUSIONS:
Although Isothymusin is already known as a conversion product of thymusin (5,6,4'-trihydroxy-6,7-dimethoxyflavone) formed by means of the Wessely-Moser rearrangement, this is the first report of Isothymusin as a plant constituent, both as aglycone and glycoside. The biogenetic and chemotaxonomic implications of the occurrence of these flavonoids in B.grandiflorum are briefly discussed.

Product Name	Isothymusin
Price:
CAS No.:	98755-25-0
Catalog No.:	CFN97562
Molecular Formula:	C₁₇H₁₄O₇
Molecular Weight:	330.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Limnophila geoffrayi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antibacterial Compound Library Flavonoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0276 mL	15.1378 mL	30.2755 mL	60.551 mL	75.6888 mL
5 mM	0.6055 mL	3.0276 mL	6.0551 mL	12.1102 mL	15.1378 mL
10 mM	0.3028 mL	1.5138 mL	3.0276 mL	6.0551 mL	7.5689 mL
50 mM	0.0606 mL	0.3028 mL	0.6055 mL	1.211 mL	1.5138 mL
100 mM	0.0303 mL	0.1514 mL	0.3028 mL	0.6055 mL	0.7569 mL

CFN97562	Isothymusin	98755-25-0	330.3	C₁₇H₁₄O₇
CFN98744	Acacetin	480-44-4	284.3	C₁₆H₁₂O₅
CFN98819	7,4'-Di-O-methylapigenin	5128-44-9	298.3	C₁₇H₁₄O₅
CFN91890	Trimethylapigenin	5631-70-9	312.32	C₁₈H₁₆O₅
CFN96380	Ladanein	10176-71-3	314.3	C₁₇H₁₄O₆
CFN99010	Pectolinarigenin	520-12-7	314.3	C₁₇H₁₄O₆
CFN99883	Salvigenin	19103-54-9	328.3	C₁₈H₁₆O₆
CFN91034	4',5,6,7-Tetramethoxyflavone	1168-42-9	342.4	C₁₉H₁₈O₆
CFN93255	6-Demethoxytangeretin	6601-66-7	342.4	C₁₉H₁₈O₆
CFN99787	Lysionotin	152743-19-6	344.32	C₁₈H₁₆O₇