Kakuol | CAS:18607-90-4 | Manufacturer ChemFaces

Kakuol

ChemFaces products have been cited in many studies from excellent and top scientific journals

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $36.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Kakuol has antifungal activity, it can completely inhibit the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 microg ml(-1) and 30 microg ml(-1), respectively. Kakuol and a derivative analogue are able to inhibit the DNA relaxation mediated by the human enzyme.

Targets:

Topoisomerase | Antifection

In vitro:

Pest Manag. Sci., 2005, 61(8):821-5.

Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome.[Pubmed: 15846774 ]

METHODS AND RESULTS:
An antifungal substance active against Colletotrichum orbiculare (Berk & Mont) Arx was isolated from the methanol extracts of Asarum sieboldii (Miq) Maek rhizomes. High-resolution MS, NMR and UV spectral data confirmed that the antifungal substance is Kakuol, 2-hydroxy-4,5-methylenedioxypropiophenone. Colletotrichum orbiculare was most sensitive to Kakuol, with MIC of 10 microg ml(-1). Kakuol also completely inhibited the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 microg ml(-1) and 30 microg ml(-1), respectively. However, no antimicrobial activity was found against yeast and bacteria even at 100 microg ml(-1). Kakuol exhibited a protective activity against the development of anthracnose disease on cucumber plants. The control efficacy of Kakuol against the anthracnose disease was in general somewhat less than that of the commercial fungicide chlorothalonil.
CONCLUSIONS:
This is the first report to demonstrate in vitro and in vivo antifungal activity of Kakuol against C. orbiculare infection.

Kakuol Description

Source:	The roots of Asarum sieboldii Miq.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Arch. Biochem. Biophys., 2013, 530(1):7-12.

A derivative of the natural compound kakuol affects DNA relaxation of topoisomerase IB inhibiting the cleavage reaction.[Pubmed: 23262316 ]

Topoisomerases IB are anticancer and antimicrobial targets whose inhibition by several natural and synthetic compounds has been documented over the last three decades.
METHODS AND RESULTS:
Here we show that Kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and a derivative analogue are able to inhibit the DNA relaxation mediated by the human enzyme. The analogue is the most efficient one and the inhibitory effect is enhanced upon pre-incubation with the enzyme. Analysis of the different steps of the catalytic cycle indicates that the inhibition occurs at the cleavage level and does not prevent DNA binding.
CONCLUSIONS:
Molecular docking shows that the compound preferentially binds near the active site at the bottom of the catalytic residue Tyr723, providing an atomistic explanation for its inhibitory activity.

Product Name	Kakuol
Price:	$222 / 20mg
CAS No.:	18607-90-4
Catalog No.:	CFN93222
Molecular Formula:	C₁₀H₁₀O₄
Molecular Weight:	194.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Asarum sieboldii Miq.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antifungal Compound Library Phenols Compound Library Topoisomerase Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.1493 mL	25.7467 mL	51.4933 mL	102.9866 mL	128.7333 mL
5 mM	1.0299 mL	5.1493 mL	10.2987 mL	20.5973 mL	25.7467 mL
10 mM	0.5149 mL	2.5747 mL	5.1493 mL	10.2987 mL	12.8733 mL
50 mM	0.103 mL	0.5149 mL	1.0299 mL	2.0597 mL	2.5747 mL
100 mM	0.0515 mL	0.2575 mL	0.5149 mL	1.0299 mL	1.2873 mL

CFN99493	Junipediol B	144881-19-6	196.2	C₁₀H₁₂O₄
CFN96122	Junipediol B 8-O-glucoside	188894-19-1	358.3	C₁₆H₂₂O₉
CFN95643	Guaiacylglycerol 8-O-beta-D-glucopyranoside	109280-40-2	376.4	C₁₆H₂₄O₁₀
CFN95644	(2R)-3-Hydroxy-2-[4-(3-hydroxypropyl)-2- methoxyphenoxy]propyl beta-D-glucopyranoside	198817-97-9	418.4	C₁₉H₃₀O₁₀
CFN95645	(2S)-3-Hydroxy-2-[4-(3-hydroxypropyl)-2- methoxyphenoxy]propyl beta-D-glucopyranoside	198817-98-0	418.4	C₁₉H₃₀O₁₀
CFN96100	threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol	848031-94-7	198.2	C₁₀H₁₄O₄
CFN96099	erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol	1280602-81-4	198.2	C₁₀H₁₄O₄
CFN98327	threo-Guaiacylglycerol	27391-16-8	214.2	C₁₀H₁₄O₅
CFN98619	erythro-Guaiacylglycerol	38916-91-5	214.2	C₁₀H₁₄O₅
CFN99804	C-Veratroylglycol	168293-10-5	212.2	C₁₀H₁₂O₅