| Sci Rep. 2014 Jul 2;4:5410. |
| Cytotoxic activity of acyl phloroglucinols isolated from the leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt.[Pubmed: 24986654] |
METHODS AND RESULTS:
Two acyl phloroglucinol compounds namely; Sideroxylonal B (1) and Macrocarpal A (2) were isolated from the Sideroxylonal-Rich Extract (SRE) of the juvenile leaves of Eucalyptus cinerea; F. Muell. ex Benth cultivated in Egypt.Meanwhile, the (SRE) together with (1) and (2) exhibited low cytotoxicity against normal cell line 10 FS, with IC₅₀ 55.4 ± 1.4, 43 ± 0.8 and 50.1 ± 1.12 μg mL-1, respectively. The antiprofilerative activity of the tested compounds was evaluated.
CONCLUSIONS:
The cell cycle profile of cells treated with Sideroxylonal-B and Macrocarpal-A indicates possible S-phase specific effects. |
| Int J Cosmet Sci. 2012 Feb;34(1):17-22. |
| Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function.[Pubmed: 21696405] |
METHODS AND RESULTS:
The addition of Macrocarpal A, one of the main components of the Eucalyptus extract, to human keratinocytes in culture increased the level of ceramide and the mRNA expression of serine palmitoyltransferase, acid sphingomyelinase, neutral sphingomyelinase, glucosylceramide synthase and glucocerebrosidase in a dose-dependent manner.
CONCLUSIONS:
Our results indicate that the increased content of ceramides in the stratum corneum may underlie the therapeutic effect of the Eucalyptus extract. Our results also indicate the possibility that Macrocarpal A is the key component that stimulates the synthesis of ceramide in the stratum corneum. |
| Agr. Biol. Chem., 1990, 54(12):3221-6. |
| Macrocarpal A, a novel antibacterial compound from Eucalyptus macrocarpa.[Reference: WebLink] |
METHODS AND RESULTS:
A novel antibacterial compound, Macrocarpal A, was isolated from the leaves of , and its structure was determined on the basis of an X-ray crystal structure analysis.
CONCLUSIONS:
Macrocarpal A is composed of a phloroglucinol dialdehyde and diterpene, having a 3-membered ring, a 5-membered ring and a 7-membered ring. |
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