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N1,N5,N10-(Z)-tri-p-coumaroylspermidine
ChemFaces products have been cited in many studies from excellent and top scientific journals
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| Size /Price /Stock |
10 mM * 1 mL in DMSO / $273.7 / In-stock |
| Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
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Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
| Related Libraries |
|
| Description: |
N1,N5,N10-(Z)-tri-p-coumaroylspermidine shows weak inhibition effect on [3H]-5-HT reuptake in rat brain synaptosomes. |
| In vitro: |
| Journal of Shanxi Medical University, 2015. | | Isolation and purification of coumaroylspermidines from Carthamus tinctorius L. and their inhibition effects on [~3H]-5-HT reuptake.[Reference: WebLink] | To isolate and purify coumaroylspermidines from Carthamus tinctorius L.,and to investigate their inhibition effects on [3H]-5-HT reuptake and the photoisomerization behavior of coumaroylspermidines.
METHODS AND RESULTS:
Coumaroyl spermidines were isolated and purified by medium pressure flash chromatography,Sephadex LH-20 column chromatographies and preparative HPLC. The chemical structures were identified by ESI-MS and1H-NMR. The inhibition effects of coumaroylspermidines on [3H]-5-HT reuptake in rat brain synaptosomes were studied by classical method. Photoisomerization behaviors of coumaroylspermidines were investigated by HPLC. Results Four coumaroylspermidines were isolated and identified as N1,N5,N10-(Z)-tri-p-coumaroylspermidine(1),
N1,N5-( Z)-N10-( E)-tri-p-coumaroylspermidine(2),N1( E)-N5-( Z)-N10-( E)-tri-p-coumaroylspermidine(3),N1,N5,N10-( E)-tri-pcoumaroylspermidine(4). Coumaroylspermidine 2 and 3 showed better inhibition effects on [3H]-5-HT reuptake in rat brain synaptosomes,while coumaroylspermidine 1 showed weaker inhibition effect. The photoisomerization behavior studies showed that the four coumaroylspermidines transformed into each other under sunlight and finally reached an equilibrium state.
CONCLUSIONS:
Coumaroylspermidines could have inhibition effects on 5-HT reuptake and the inhibition effects could be different for different isomers. Coumaroylspermidines are unstable and could show photoisomerization behavior under sunlight. |
|
N1,N5,N10-(Z)-tri-p-coumaroylspermidine Description
| Source: |
The herbs of Helianthus annuus L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.7132 mL |
8.566 mL |
17.1321 mL |
34.2642 mL |
42.8302 mL |
| 5 mM |
0.3426 mL |
1.7132 mL |
3.4264 mL |
6.8528 mL |
8.566 mL |
| 10 mM |
0.1713 mL |
0.8566 mL |
1.7132 mL |
3.4264 mL |
4.283 mL |
| 50 mM |
0.0343 mL |
0.1713 mL |
0.3426 mL |
0.6853 mL |
0.8566 mL |
| 100 mM |
0.0171 mL |
0.0857 mL |
0.1713 mL |
0.3426 mL |
0.4283 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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