Napellonine | CAS:509-24-0 | Manufacturer ChemFaces

Napellonine

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $42.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

Targets:

FGFR4

In vivo:

Sci Rep. 2017 Jun 15;7(1):3569.

A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine.[Pubmed: 28620157 ]

We describe a novel biomembrane affinity sample pretreatment technique to quickly screen and preconcentrate active components from traditional Chinese medicine (TCM), which adopts cell membrane coated silica particles (CMCSPs) as affinity ligands which benefit the biomembrane's ability to maximize simulation of drug-receptor interactions in vivo.
METHODS AND RESULTS:
In this study, the prepared CMCSPs formed by irreversible adsorption of fibroblast growth factor receptor 4 (FGFR4) cell membrane on the surface of silica were characterized using different spectroscopic and imaging instruments. Drug binding experiments showed the excellent adsorption rate and adsorption capacity of FGFR4/CMCSPs compared with non-coated silica particles. The FGFR4/CMCSPs were used as solid-phase extraction sorbents to pretreat the TCM Aconitum szechenyianum Gay. The resultant FGFR4/CMCSPs exhibited good performance. In addition, high selectivity and recognition ability of the FGFR4/CMCSPs were determined by selectivity experiments. Four alkaloid were screened and identified, one of these alkaloid, Napellonine, showed favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
CONCLUSIONS:
The proposed cell membrane affinity sample pretreatment method is a reliable, effective and time-saving method for fast screening and enriching active compounds and can be extended to pretreat other TCMs as leading compounds resources.

Napellonine Description

Source:	The roots of Aconitumso ngoricum Popov
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Napellonine
Price:	$218 / 20mg
CAS No.:	509-24-0
Catalog No.:	CFN90393
Molecular Formula:	C₂₂H₃₁NO₃
Molecular Weight:	357.49 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The roots of Aconitumso ngoricum Popov
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7973 mL	13.9864 mL	27.9728 mL	55.9456 mL	69.932 mL
5 mM	0.5595 mL	2.7973 mL	5.5946 mL	11.1891 mL	13.9864 mL
10 mM	0.2797 mL	1.3986 mL	2.7973 mL	5.5946 mL	6.9932 mL
50 mM	0.0559 mL	0.2797 mL	0.5595 mL	1.1189 mL	1.3986 mL
100 mM	0.028 mL	0.1399 mL	0.2797 mL	0.5595 mL	0.6993 mL

CFN90228	Bullatine A	1354-84-3	343.51	C₂₂H₃₃NO₂
CFN93074	Karacoline	39089-30-0	377.52	C₂₂H₃₅NO₄
CFN91495	Guan-fu base A	1394-48-5	429.5	C₂₄H₃₁NO₆
CFN89550	Delgrandine	145237-05-4	741.77	C₄₁H₄₃NO₁₂
CFN89547	14-Dehydrodelcosine	1361-18-8	451.55	C₂₄H₃₇NO₇
CFN99502	Acoforestinine	110011-77-3	645.79	C₃₅H₅₁NO₁₀
CFN89329	8-Deacetylyunaconitine	93460-55-0	617.73	C₃₃H₄₇NO₁₀
CFN99503	Yunaconitine	70578-24-4	659.77	C₃₅H₄₉NO₁₁
CFN89362	3-Acetylyunaconitine	80787-51-5	701.80	C₃₇H₅₁NO₁₂
CFN99720	Bulleyaconitine A	107668-79-1	643.8	C₃₅H₄₉NO₁₀