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(-)-beta-Peltatin
(-)-beta-Peltatin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name (-)-beta-Peltatin
Price:
CAS No.: 518-29-6
Catalog No.: CFN92699
Molecular Formula: C22H22O8
Molecular Weight: 414.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Podophyllum peltatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (-)-beta-Peltatin has antimitotic, and antineoplastic activities.
In vitro:
Pesticide Biochemistry and Physiology, 2002, 72(1):45-54.
Aryltetralin Lignans Inhibit Plant Growth by Affecting the Formation of Mitotic Microtubular Organizing Centers.[Reference: WebLink]

METHODS AND RESULTS:
The aryltetralin lignans podophyllotoxin, α-peltatin, and β-peltatin((-)-beta-Peltatin ), their respective O-β-d-glucosides, and the semisynthetic derivative etoposide were tested for phytotoxicity. The aglycones were more potent inhibitors than their respective glucosides, and podophyllotoxin was the most active natural lignan tested. These compounds were more active against rye (Lolium multiflorum L.) and onion (Allium cepa L.) than lettuce (Lactuca sativa L.). The semisynthetic lignan etoposide was more active than any of the natural analogues and was phytotoxic to both monocotyledonous and dicotyledonous species. Inhibition of root growth was the main developmental response observed on plants tested with the lignans. At the cellular level, podophyllotoxin and etoposide caused similar symptoms in actively dividing meristematic cells of onion root tips. All phases of mitosis were inhibited by nearly 50%, relative to the controls. Both compounds also induced abnormal star anaphase chromosomal configurations.
CONCLUSIONS:
While the precise molecular mechanism of action of these compounds remains to be identified in plants, a primary effect is the alteration of the formation of the spindle microtubular organization centers, resulting in the formation of multiple spindle poles and an asymmetrical convergence of the chromosomes.
(-)-beta-Peltatin Description
Source: The herbs of Podophyllum peltatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4131 mL 12.0656 mL 24.1313 mL 48.2625 mL 60.3282 mL
5 mM 0.4826 mL 2.4131 mL 4.8263 mL 9.6525 mL 12.0656 mL
10 mM 0.2413 mL 1.2066 mL 2.4131 mL 4.8263 mL 6.0328 mL
50 mM 0.0483 mL 0.2413 mL 0.4826 mL 0.9653 mL 1.2066 mL
100 mM 0.0241 mL 0.1207 mL 0.2413 mL 0.4826 mL 0.6033 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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CAS No: 518-17-2
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Roemerine

Catalog No: CFN91019
CAS No: 548-08-3
Price: $318/5mg
Linolenic acid

Catalog No: CFN70110
CAS No: 463-40-1
Price: $30/20mg
Scoparone

Catalog No: CFN99314
CAS No: 120-08-1
Price: $30/20mg
Phillygenin

Catalog No: CFN90511
CAS No: 487-39-8
Price: $118/20mg
Quercetin

Catalog No: CFN99272
CAS No: 117-39-5
Price: $40/20mg
Timosaponin A3

Catalog No: CFN98151
CAS No: 41059-79-4
Price: $50/20mg
Vaccarin

Catalog No: CFN90131
CAS No: 53452-16-7
Price: $30/20mg
Cyclocurcumin

Catalog No: CFN95103
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Ginsenoside Rd

Catalog No: CFN99975
CAS No: 52705-93-8
Price: $30/20mg
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