Picrasidine Q | CAS:101219-61-8 | Manufacturer ChemFaces

Picrasidine Q

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Picrasidine Q
Price:	$318 / 10mg
CAS No.:	101219-61-8
Catalog No.:	CFN92205
Molecular Formula:	C₁₅H₁₀N₂O₃
Molecular Weight:	266.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The barks of Picrasma quassioides.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $144.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Picrasidine Q Description

Source:	The barks of Picrasma quassioides.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Journal of Cellular Biochemistry, 2017, 119(2).

FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma.[Pubmed: 28857247]

Fibroblast growth factor receptor (FGFR) 2 and its downstream signaling cascades, PI3 K/AKT/mTOR is playing an important role in cell survival and proliferations.
METHODS AND RESULTS:
In this study, we firstly found that Picrasidine Q (PQ), an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. After ligand shape similarity approach of PQ, we found that PQ targeted FGFR 2 and verified by FGFR2 kinase assay as well as computational docking model. FGFR2 highly expressed in esophageal cancer tissues and PQ inhibited fibroblast growth factor (FGF)-induced cell transformation. Furthermore, PQ inhibited cell proliferation and induced cell cycle arrest and apoptosis in KYSE30, KYSE410, and KYSE450 esophageal squamous cell carcinoma (ESCC) cells. It was confirmed by detecting of biological markers such as cyclinD1, cyclinD3 and cyclinB1 for cell cycle or cleaved caspase-7, caspase-3, and PARP for apoptosis. PQ targeting of FGFR2 kinase activities suppressed downstream target proteins including phosphorylation of AKT and mTOR but not MEK/ERK signaling pathways.
CONCLUSIONS:
Taken together, our results are the first to identify that PQ might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library mTOR Inhibitor Library Akt Inhibitor Library

Description:	Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
Targets:	FGFR2 \| PI3 K \| AKT \| mTOR

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7552 mL	18.7758 mL	37.5516 mL	75.1033 mL	93.8791 mL
5 mM	0.751 mL	3.7552 mL	7.5103 mL	15.0207 mL	18.7758 mL
10 mM	0.3755 mL	1.8776 mL	3.7552 mL	7.5103 mL	9.3879 mL
50 mM	0.0751 mL	0.3755 mL	0.751 mL	1.5021 mL	1.8776 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.751 mL	0.9388 mL

CFN92128	4,9-Dimethoxycanthin-6-one	1270001-72-3	280.3	C₁₆H₁₂N₂O₃
CFN92930	5-Hydroxy-canthin-6-one	64118-73-6	236.23	C₁₄H₈N₂O₂
CFN92362	5-Methoxycanthin-6-one	15071-56-4	250.3	C₁₅H₁₀N₂O₂
CFN92205	Picrasidine Q	101219-61-8	266.3	C₁₅H₁₀N₂O₃
CFN99846	5-Hydroxy-4-methoxycanthin-6-one	18110-86-6	266.3	C₁₅H₁₀N₂O₃
CFN99847	4,5-Dimethoxycanthin-6-one	18110-87-7	280.3	C₁₆H₁₂N₂O₃