Pinoresinol 4-O-beta-D-glucopyranoside | CAS:69251-96-3

Pinoresinol 4-O-beta-D-glucopyranoside

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Product Name	Pinoresinol 4-O-beta-D-glucopyranoside
Price:	$100 / 20mg
CAS No.:	69251-96-3
Catalog No.:	CFN97180
Molecular Formula:	C₂₆H₃₂O₁₁
Molecular Weight:	520.5 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The rhizomes of Polygonatum sibiricum Red.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $37.4 / In-stock
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Description:

(+)-Pinoresinol 4-O-beta-D-glucopyranoside revealed that the presence of a vanilloyl group in the sugar moiety of (+)-pinoresinol 4-O-[6″-O-vanilloyl]-β-D-glucopyranoside is crucial for its anti-influenza virus activity.

In vitro:

PLoS One. 2014 Aug 7;9(8):e104544.

In vitro anti-influenza virus activities of a new lignan glycoside from the latex of Calotropis gigantea.[Pubmed: 25102000]

A new lignan glycoside, (+)-pinoresinol 4-O-[6″-O-vanilloyl]-β-D-glucopyranoside (1) and two known phenolic compounds, 6'-O-vanilloyltachioside (2) and 6'-O-vanilloylisotachioside (3) were isolated from the latex of Calotropis gigantea (Asclepiadaceae).
METHODS AND RESULTS:
The structure of the new compound was elucidated by using spectroscopic and chemical methods. Three isolates (1-3) and one authentic compound, (+)- Pinoresinol 4-O-beta-D-glucopyranoside, were screened for A/PR/8/34 (H1N1) inhibitory activity by cytopathic effect (CPE) inhibition assay on MDCK cells. Compound 1 showed inhibitory activity against A/PR/8/34 (H1N1). In sharp contrast, the other three compounds (2, 3 and (+)-Pinoresinol 4-O-beta-D-glucopyranoside) did not show such activity. An analysis of structure-activity relationship between 1 and (+)-Pinoresinol 4-O-beta-D-glucopyranoside revealed that the presence of a vanilloyl group in the sugar moiety of 1 is crucial for its anti-influenza virus activity. Compound 1 was further evaluated for in vitro inhibitory activities against a panel of human and avian influenza viruses by CPE inhibition assay. It showed inhibitory effect against human influenza viruses in both subtypes A and B (IC50 values around 13.4-39.8 µM with SI values of 3.7-11.4), while had no effect on avian influenza viruses. Its antiviral activity against human influenza viruses subtype A was further confirmed by plaque reduction assay. The time course assay indicated that 1 exerts its antiviral activity at the early stage of viral replication. A mechanistic study showed that 1 efficiently inhibited influenza virus-induced activation of NF-κB pathway in a dose-dependent manner, but had no effect on virus-induced activation of Raf/MEK/ERK pathway. Further studies demonstrated that nuclear translocation of transcription factor NF-κB induced by influenza virus was significantly blocked by 1, meanwhile, nuclear export of viral ribonucleoproteins was also effectively inhibited.
CONCLUSIONS:
These findings suggest that this new lignan glycoside from Calotropis gigantea, may have therapeutic potential in influenza virus infection through inhibition of NF-κB pathway and viral ribonucleoproteins nuclear export.

Pinoresinol 4-O-beta-D-glucopyranoside Description

Source:	The rhizomes of Polygonatum sibiricum Red.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9212 mL	9.6061 mL	19.2123 mL	38.4246 mL	48.0307 mL
5 mM	0.3842 mL	1.9212 mL	3.8425 mL	7.6849 mL	9.6061 mL
10 mM	0.1921 mL	0.9606 mL	1.9212 mL	3.8425 mL	4.8031 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.7685 mL	0.9606 mL
100 mM	0.0192 mL	0.0961 mL	0.1921 mL	0.3842 mL	0.4803 mL

CFN00449	8-Acetoxypinoresinol	81426-14-4	416.43	C₂₂H₂₄O₈
CFN90676	Herpetone	951677-22-8	522.54	C₂₉H₃₀O₉
CFN96416	Yangambin	13060-14-5	446.49	C₂₄H₃₀O₈
CFN96723	Epiyangambin	24192-64-1	446.49	C₂₄H₃₀O₈
CFN98775	Pinoresinol	487-36-5	358.4	C₂₀H₂₂O₆
CFN90879	Pinoresinol dimethyl ether	29106-36-3	386.4	C₂₂H₂₆O₆
CFN96266	Eudesmin	526-06-7	386.4	C₂₂H₂₆O₆
CFN96935	3,4,5'-Trimethoxy-3',4'-methylenedioxy-7,9':7',9-diepoxylignan	873867-94-8	400.42	C₂₂H₂₄O₇
CFN98420	Pinoresinol diacetate	32971-25-8	442.5	C₂₄H₂₆O₈
CFN97180	Pinoresinol 4-O-beta-D-glucopyranoside	69251-96-3	520.5	C₂₆H₃₂O₁₁