Rhaponticin 2''-O-gallate | CAS:94356-24-8

Rhaponticin 2''-O-gallate

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Description:

Rhaponticin 2''-O-gallate showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).

Targets:

In vitro:

Bioorg Med Chem Lett. 2000 Feb 21;10(4):323-7.

Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages.[Pubmed: 10714491 ]

METHODS AND RESULTS:
Two new anthraquinone glucosides [chrysophanol 8-O-beta-D-(6'-galloyl)-glucopyranoside, aloe-emodin 1-O-beta-D-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-beta-D-glucopyranoside), and two stilbene glucoside gallates (Rhaponticin 2''-O-gallate, Rhaponticin 6''-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
CONCLUSIONS:
The oxygen functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the alpha,beta-double bond did not affect the activity. Furthermore, the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction.

Rhaponticin 2''-O-gallate Description

Source:	The roots of Rumex obtusifolius L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Rhaponticin 2''-O-gallate
Price:	$288 / 5mg
CAS No.:	94356-24-8
Catalog No.:	CFN91100
Molecular Formula:	C₂₈H₂₈O₁₃
Molecular Weight:	572.51 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Rumex obtusifolius L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7467 mL	8.7335 mL	17.4669 mL	34.9339 mL	43.6674 mL
5 mM	0.3493 mL	1.7467 mL	3.4934 mL	6.9868 mL	8.7335 mL
10 mM	0.1747 mL	0.8733 mL	1.7467 mL	3.4934 mL	4.3667 mL
50 mM	0.0349 mL	0.1747 mL	0.3493 mL	0.6987 mL	0.8733 mL
100 mM	0.0175 mL	0.0873 mL	0.1747 mL	0.3493 mL	0.4367 mL

CFN90874	Trimethoxystilbene	22255-22-7	270.3	C₁₇H₁₈O₃
CFN89540	3,5-Dimethoxy-3'-hydroxybibenzyl	168281-05-8	258.31	C₁₆H₁₈O₃
CFN90118	Desoxyanisoin	120-44-5	256.30	C₁₆H₁₆O₃
CFN91179	Arundinin	148225-38-1	350.4	C₂₂H₂₂O₄
CFN95511	2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF)	67121-26-0	270.2	C₁₅H₁₀O₅
CFN98791	Resveratrol	501-36-0	228.2	C₁₄H₁₂O₃
CFN90895	Triacetylresveratrol	42206-94-0	354.4	C₂₀H₁₈O₆
CFN99159	Polydatin	27208-80-6	390.40	C₂₀H₂₂O₈
CFN95226	Pieceid-2''-O-gallate	64898-03-9	542.5	C₂₇H₂₆O₁₂
CFN98987	Dihydroresveratrol	58436-28-5	230.3	C₁₄H₁₄O₃