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Seneganolide
Seneganolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Seneganolide
Price:
CAS No.: 301530-12-1
Catalog No.: CFN98376
Molecular Formula: C26H30O8
Molecular Weight: 470.5 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The heartwoods of Khaya senegalensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Seneganolide has insect antifeeding activity. Seneganolide A has antifungal activity.
Targets: Antifection
In vitro:
Fitoterapia. 2004 Sep;75(6):566-72.
Antifungal limonoids from the fruits of Khaya senegalensis.[Pubmed: 15351110]

METHODS AND RESULTS:
Investigation of the fruits of Khaya senegalensis resulted in the isolation of three new mexicanolide limonoids containing a rare conjugated diene lactone system named Seneganolide A (1), 2-hydroxySeneganolide A (2) and 2-acetoxySeneganolide A (3). Two known limonoids, 3-deacetyl-7-deacetoxy-7-oxokhivorin (4) and methyl 6-hydroxyangolensate (5), were also found. The structures of the new compounds were elucidated on the basis of spectral methods.
CONCLUSIONS:
The antifungal activity of compounds Seneganolide A, 3 and 5 was tested against the fungus Botrytis cinerea.
Chemistry letters, 2000(8):876-877.
Seneganolide, a Novel Antifeeding Mexicanolide from Khaya senegalensis[Reference: WebLink]

METHODS AND RESULTS:
Seneganolide, a Novel Antifeeding Mexicanolide from Khaya senegalensis.
Seneganolide Description
Source: The heartwoods of Khaya senegalensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1254 mL 10.627 mL 21.254 mL 42.508 mL 53.135 mL
5 mM 0.4251 mL 2.1254 mL 4.2508 mL 8.5016 mL 10.627 mL
10 mM 0.2125 mL 1.0627 mL 2.1254 mL 4.2508 mL 5.3135 mL
50 mM 0.0425 mL 0.2125 mL 0.4251 mL 0.8502 mL 1.0627 mL
100 mM 0.0213 mL 0.1063 mL 0.2125 mL 0.4251 mL 0.5313 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Molecules. 2014 Mar 7;19(3):3004-11.
Limonoids from the fruits of Khaya ivorensis.[Pubmed: 24609020]

METHODS AND RESULTS:
Two new limonoids, namely 14,15-didehydroruageanin A (1) and 3-O-methyl- butyrylSeneganolide A (2), were isolated from the fruits of Khaya ivorensis along with six known limonoids: Seneganolide A (3), 1,3-dideacetylkhivorin (4), 7-deacetylkhivorin (5), 3-deacetylkhivorin (6), 1-deacetylkhivorin (7), and 3-deacetyl-7-oxokhivorin (8). All the compounds were evaluated for their cytotoxicity against five tumor cell lines.
CFN98209Methyl 6-hydroxyangolensate22255-07-8486.6 C27H34O8
CFN99699Methyl 6-acetoxyangolensate16566-88-4528.6 C29H36O9
CFN982696-Deoxy-9alpha-hydroxycedrodorin247036-52-8502.6 C27H34O9
CFN99337Khayalenoid E1220508-29-1526.6 C29H34O9
CFN98376Seneganolide301530-12-1470.5 C26H30O8
CFN990231-O-Deacetylkhayanolide E1007387-95-2516.6 C27H32O10
CFN992981-O-Deacetyl-2alpha-hydroxykhayanolide E1189801-51-1532.5 C27H32O11
CFN96576Swietemahalactone1514669-21-6514.52C27H30O10
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