Taccalonolide A | CAS:108885-68-3 | Manufacturer ChemFaces

Taccalonolide A

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Product Name	Taccalonolide A
Price:	$288 / 10mg
CAS No.:	108885-68-3
Catalog No.:	CFN90596
Molecular Formula:	C₃₆H₄₆O₁₄
Molecular Weight:	702.74 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The rhizomes of Schizocapsa plantaginea Hance
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $187.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Taccalonolide A Description

Source:	The rhizomes of Schizocapsa plantaginea Hance
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

April 12, 2005

Taccalonolide microtubule stabilizing agents[Reference: WebLink]

In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling.
METHODS AND RESULTS:
Bioassay-directed purification yields the steroid Taccalonolide A. Taccalonolide, like paclitaxel, initiates the formation of abnormal interphaes and mitotic microtubules. Cells treated with taccalonolide exhibit thick bundles of microtubules that appear to nucleate independent of the microtubule organizing center. Abnormal mitotic spindles consisting of multi-polar spindles are initiated by Taccalonolide And resemble abnormal mitotic spindles found in the presence of paclitaxel. Like paclitaxel, taccalonolide causes the breakdown of the nucleus into micronuclei. Taccalonolide causes G2/M arrest, Bc1-2 phosphorylation and initiates an apoptotic cascade that includes the activation of caspase 3. Taccalonolide is an effective inhibitor of proliferation against both SK-OV-3 and MDA-MB-435 cell with IC50 values of 2.3 μM and 2.1 μM respectively. In contrast to paclitaxel, taccalonolide is effective against the multidrug resistant SKVLB-1 cellline and thus appears to be a poor substrate for P-glycoprotein-mediated transport. Although taccalonolide is almost equipotent with paclitaxel in its effects on cellular microtubules, it is much less potent than paclitaxel in its ability to initiate the polymerization of purified tubulin and microtubule protein.
CONCLUSIONS:
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Microtubule stabilizers Compound Library Anti-trypanosoma Compound Library Steroids Compound Library P-gp Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

Description:	Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects.
Targets:	Bcl-2/Bax \| Caspase \| P-gp

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.423 mL	7.115 mL	14.23 mL	28.46 mL	35.575 mL
5 mM	0.2846 mL	1.423 mL	2.846 mL	5.692 mL	7.115 mL
10 mM	0.1423 mL	0.7115 mL	1.423 mL	2.846 mL	3.5575 mL
50 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.5692 mL	0.7115 mL
100 mM	0.0142 mL	0.0712 mL	0.1423 mL	0.2846 mL	0.3558 mL

CFN95097	Physalin O	120849-18-5	528.55	C₂₈H₃₂O₁₀
CFN92936	Isophysalin A	1363398-67-7	526.5	C₂₈H₃₀O₁₀
CFN92938	Physalin C	27503-33-9	510.53	C₂₈H₃₀O₉
CFN92941	Physalin B	23133-56-4	510.53	C₂₈H₃₀O₉
CFN91433	3beta-Methoxy-2,3-dihydro-4,7-didehydrophysalin B	1173241-82-1	540.6	C₂₉H₃₂O₁₀
CFN92939	Physalin D	54980-22-2	544.55	C₂₈H₃₂O₁₁
CFN91811	Physalin F	57423-71-9	526.5	C₂₈H₃₀O₁₀
CFN95104	Physalin G	76045-38-0	526.5	C₂₈H₃₀O₁₀
CFN95328	Isophysalin G	152221-21-1	526.5	C₂₈H₃₀O₁₀
CFN92937	Physalin H	70241-09-7	562.99	C₂₈H₃₁ClO₁₀