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Terchebulin
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Product Name Terchebulin
Price:
CAS No.: 132854-40-1
Catalog No.: CFN92297
Molecular Formula: C48H28O30
Molecular Weight: 1084.7 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The fruits of Terminalia chebula
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
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Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Terchebulin has potentiality as an anti-acne agent, it shows good antibacterial activity against Propionibacterium acnes, minimum inhibitory concentration (MIC) = 125 ug/ml and minimum bactericidal concentration (MBC) = 250 ug/ml.Terchebulin, flavogallonic acid and punicalagin have antiplasmodial activity, the IC50s of them range between 8-21 microg/ml (8-40 microM) against Plasmodium falciparum 3D7 and K1.
Targets: Antifection
In vitro:
Parasitol. Res., 2008, 102(6):1119-27.
The use of microfluorometric method for activity-guided isolation of antiplasmodial compound from plant extracts.[Pubmed: 18214539 ]
In vitro antiplasmodial activity of methanolic extracts of 16 medicinal plants was evaluated by fluorometric assay using PicoGreen.
METHODS AND RESULTS:
The IC50s, as determined by parasite DNA concentration, ranged from <11 to >200 and <13 to >200 microg/ml for Plasmodium falciparum 3D7 and K1, respectively; and the most active extracts were those from Anogeissus leiocarpus and Terminalia avicennoides (<11-> or =14 microg/ml). Aqueous, butanolic, ethyl acetate, and methanolic fractions of these two extracts revealed butanolic fraction to have a relatively better activity (IC50, 10-12 microg/ml). Activity-guided chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by nuclear magnetic resonance and correlation high-performance liquid chromatography revealed the presence of known hydrolysable tannins and some related compounds-castalagin, ellagic acid, flavogallonic acid, punicalagin, Terchebulin, and two other fractions.
CONCLUSIONS:
The IC50s of all these compounds ranged between 8-21 microg/ml (8-40 microM) against both the strains. Toxicity assay with mouse fibroblasts showed all the extracts and isolated compounds to have IC50 > or = 1500 microg/ml, except for Momordica balsamina with <1500 microg/l. All the extracts and isolated compounds did not affect the integrity of human erythrocyte membrane at the observed IC50s. However, adverse effects manifest in a concentration-dependent fashion (from IC50 > or = 500 microg/ml).
J. Wood Sci., 2013, 59(5):426-31.
Anti-acne activity of tannin-related compounds isolated from Terminalia laxiflora[Reference: WebLink]
In our investigation to find out new anti-acne agent, we focused on Terminalia laxiflora Engl & Diels (Combretaceae) methanolic wood extract, which has been selected during previous screening experiments for anti-acne agents, which included 29 species of Sudanese medicinal plants.
METHODS AND RESULTS:
Based on the biologically guided fractionation using an antibacterial assay against Propionibacterium acnes, a lipase inhibitory assay and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity assay; five tannin-related compounds were isolated, such as ellagic acid, flavogallonic acid dilactone, Terchebulin and gallic acid. Terchebulin showed good antibacterial activity; minimum inhibitory concentration (MIC) = 125 μg/ml and minimum bactericidal concentration (MBC) = 250 μg/ml. Gallic acid exhibited lipase inhibitory activity with IC50 value of 149.3 μM, which showed strong inhibition compared with Terchebulin, IC50 260.7 μM. However, all compounds exhibited better or equal DPPH radical scavenging activity to (+)-catechin as positive control. Ellagic acid and Terchebulin showed the best DPPH radical scavenging activities, IC50 4.86 and 4.90 μM, respectively.
CONCLUSIONS:
This study demonstrated that Terchebulin has potentiality as an anti-acne agent.
Terchebulin Description
Source: The fruits of Terminalia chebula
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.9219 mL 4.6096 mL 9.2191 mL 18.4383 mL 23.0478 mL
5 mM 0.1844 mL 0.9219 mL 1.8438 mL 3.6877 mL 4.6096 mL
10 mM 0.0922 mL 0.461 mL 0.9219 mL 1.8438 mL 2.3048 mL
50 mM 0.0184 mL 0.0922 mL 0.1844 mL 0.3688 mL 0.461 mL
100 mM 0.0092 mL 0.0461 mL 0.0922 mL 0.1844 mL 0.2305 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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