Wilfordine | CAS:37239-51-3 | Manufacturer ChemFaces

Wilfordine

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Description:

Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.

Targets:

Sodium Channel | ATPase | Potassium Channel

In vivo:

Chinese Journal of Pesticide Science, 2008, 10(1): 75-9.

Contact Action of Wilfordine and Wilforine from Tripterygium hypoglaucum and their Effects on Na~+-K~+-ATPase Activities of Mythimna separata[Reference: WebLink]

Wilfordine and wilforine with contact toxicity against some larvae of insect,were isolated from the insecticidal plants of Tripterygium hypoglaucum.
METHODS AND RESULTS:
For investigating their insecticidal mechanism,their poisoning symptoms were observed when Wilfordine and wilforine were applied on the pronoturm of Mythimna separata by topical application.The results showed that the larvae were narcotized after 2 hours,revived completely after 8 hours,then narcotized again after 24 hours,part of the larvae were dead after 48 hours.The results also showed that the medium narcosis dose(ND50) of Wilfordine and wilforine were 8.82 μg/larva,4.58 μg/larvae against the 3rd instar larvae of M.separata respectively.The ND50 of Wilfordine and wilforine were 4.71 μg/larva,3.46 μg/larva against the 3rd instar larvae Plutella xylostella respectively.In vitro and in vivo,the effects of Wilfordine and wilforine on Na+-K+-ATPase from the head of the 5th instar larvae of M.separata were investigated.
CONCLUSIONS:
The results showed that the Na+-K+-ATPase in the central nervous system was inhibited by Wilfordine and wilforine,and the inhibition rate was dependant on the concentration.It suggested that Na+-K+-ATPase may be an acting target of Wilfordine and wilforine against some larvae of insect.

Wilfordine Description

Source:	The roots of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Wilfordine
Price:
CAS No.:	37239-51-3
Catalog No.:	CFN92103
Molecular Formula:	C₄₃H₄₉NO₁₉
Molecular Weight:	883.9 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insecticides Compound Library Sesquiterpenoids Compound Library Sodium Channel Inhibitor Library Potassium Channel Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1313 mL	5.6567 mL	11.3135 mL	22.627 mL	28.2837 mL
5 mM	0.2263 mL	1.1313 mL	2.2627 mL	4.5254 mL	5.6567 mL
10 mM	0.1131 mL	0.5657 mL	1.1313 mL	2.2627 mL	2.8284 mL
50 mM	0.0226 mL	0.1131 mL	0.2263 mL	0.4525 mL	0.5657 mL
100 mM	0.0113 mL	0.0566 mL	0.1131 mL	0.2263 mL	0.2828 mL

CFN92120	Wilfornine A	345954-00-9	925.9	C₄₅H₅₁NO₂₀
CFN99207	Wilforine	11088-09-8	867.9	C₄₃H₄₉NO₁₈
CFN92121	Alatamine	41855-33-8	839.8	C₄₁H₄₅NO₁₈
CFN92103	Wilfordine	37239-51-3	883.9	C₄₃H₄₉NO₁₉
CFN92104	Peritassine A	150881-01-9	805.8	C₃₈H₄₇NO₁₈
CFN92118	Ebenifoline E-II	133740-16-6	929.9	C₄₈H₅₁NO₁₈
CFN92119	Mayteine	104736-05-2	867.9	C₄₃H₄₉NO₁₈