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erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
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CAS No.: 613684-55-2
Catalog No.: CFN96718
Molecular Formula: C31H36O11
Molecular Weight: 584.61 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The seed shell of Hevea brasiliensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether shows inhibitory activity against human leukocyte elastase with the IC50 value of 171 umol·L-1.
In vitro:
Chinese Journal of New Drugs, 2012, 21(19):2311-2315.
Chemical constituents of the seed shell of Hevea brasiliensis.[Reference: WebLink]
To study the chemical constituents of the seed shell of Hevea brasiliensis.
METHODS AND RESULTS:
The compounds were isolated by chromatography on silica gel, LH-20, ODS-C18 and HPLC. Their structures were identified by physicochemical and spectral analysis. MTT assays in vitro were used to explore the inhibitory effect of these compounds on B16 cancer cells, and a high through-put screening method was used to explore the HLE inhibitors. Nine compounds were isolated and identified as vanillin(1), coniferaldehyde(2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether(3), threo-guaiacylglycerol-β-coniferyl aldehyde ether(4), (-)-balanophonin(5), isoamericanol A (6), americanol A (7),erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether (8), and buddlenol A (9). Compound 9 showed anti-tumor activity against B16 cancer cells with IC50 value of 20.6 μmol·L-1. Compounds 5~9 showed inhibitory activity against human leukocyte elastase with IC50 values of 168, 45.5, 57.6, 171 and 115 μmol·L-1, respectively.
CONCLUSIONS:
All compounds were isolated from this plant for the first time. Compound 9 showed inhibitory activity on B16 cancer cells, and compounds 5~9 were reported as human leukocyte elastase inhibitors for the first time.
erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether Description
Source: The seed shell of Hevea brasiliensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7105 mL 8.5527 mL 17.1054 mL 34.2108 mL 42.7636 mL
5 mM 0.3421 mL 1.7105 mL 3.4211 mL 6.8422 mL 8.5527 mL
10 mM 0.1711 mL 0.8553 mL 1.7105 mL 3.4211 mL 4.2764 mL
50 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.6842 mL 0.8553 mL
100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.3421 mL 0.4276 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Ginsenoside Re

Catalog No: CFN99974
CAS No: 52286-59-6
Price: $40/20mg
Hederagenin

Catalog No: CFN98695
CAS No: 465-99-6
Price: $30/20mg
Estragole

Catalog No: CFN70065
CAS No: 140-67-0
Price: $30/20mg
D-(-)-Salicin

Catalog No: CFN99541
CAS No: 138-52-3
Price: $30/20mg
Pyrogallol

Catalog No: CFN97443
CAS No: 87-66-1
Price: $30/20mg
Dehydromiltirone

Catalog No: CFN98532
CAS No: 116064-77-8
Price: $438/5mg
Pinostrobin

Catalog No: CFN98739
CAS No: 480-37-5
Price: $218/20mg
Pterostilbene

Catalog No: CFN90397
CAS No: 537-42-8
Price: $40/20mg
Coelonin

Catalog No: CFN92693
CAS No: 82344-82-9
Price: $388/5mg
Aloenin A

Catalog No: CFN93235
CAS No: 38412-46-3
Price: $ / mg
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