Bioactive Products
| A unique collection of 518 natural compounds with Antioxidants biological activity for high throughput screening (HTS) and high content screening (HCS) | ||
| Catalog No: | B11 | Antioxidants Compound Library Screening Details |
| Size: | 1mg/well * 518 Compounds 2mg/well * 518 Compounds | |
| Cat. No. | Information |
| CFN99560 | Procyanidin C1 Procyanidin C1 has anti-inflammatory effects, can inhibit IKKb activity in vitro and reduce the LPS-induced production of ROS, thus, it exerts the anti-inflammatory effects by inhibiting ERK1/2 and IKKb activity. Procyanidin C1 could be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to epithelial-to-mesenchymal transition (EMT). Procyanidin C1 may represent a novel and potentially therapeutically relevant compound for the treatment of cardiovascular diseases, it -induced vasorelaxation is associated with the activation of the calcium-dependent NO/cGMP pathway, involving potassium channel activation. |
| CFN99562 | Berberine hydrochloride Berberine hydrochloride has anticancer, antifungi, anti-inflammatory, and anti-oxidant activities, it can significantly attenuate neutrophil infiltration, suppress myeloperoxidase activity, decrease NO, TNF-αand IL-1βproduction, inhibits the phosphorylation of the NF-κB p65 subunit and the degradation of its inhibitor, IκBα. |
| CFN99563 | Coptisine Coptisine is an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM, it can consequently prevent neuron loss, reduce amyloid plaque formation, and ameliorate impaired cognition, it could as a potential new class of drugs for AD treatment. Coptisine has cardioprotection, anti- hypercholesterolemia, anti-fungal, anti-osteosarcoma, anti-hepatoma and anti-leukaemia activities, it also has antispasmodic and relaxant activity on a guinea-pig ileum. |
| CFN99565 | Picroside I Picroside I is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug candidates for cancer therapy by suppressing Collagenases and Gelatinases. Picroside I can enhance basic fibroblast growth factor(bFGF)-, staurosporine- or dbc-mitogen-activated protein (MAP)-induced neurite outgrowth from PC12D cells. |
| CFN99566 | Picroside II Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities. It has potent anti-apoptotic activity against renal I/R injury by suppressing the TLR4/NF-κB signaling pathway, it can protect the ischemic kidney against renal fibrosis and improve the neurological function of rats upon cerebral ischemia reperfusion injury. Picroside II enhances nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells by amplifying a down-stream step of MAP kinase in the NGF receptor-mediated intracellular MAP kinase-dependent signaling pathway. |
