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Bioactive Products
Neuroprotection Compound Library
A unique collection of 223 Neuroprotection natural compounds for high throughput screening (HTS)
Catalog No: B72a21 Neuroprotection Compound Library
Screening Details
Size: 1mg/well * 223 Compounds
2mg/well * 223 Compounds
Cat. No. Information
CFN90153 Sauchinone

Sauchinone possesses diverse pharmacological properties, such as hepatoprotective, neuroprotective, anti-inflammatory and anti-tumor effects. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Sauchinone can be used for the prevention of functional β-cell damage, it prevents cytokine-induced NO production, iNOS expression,JAK/STAT activation,and NF-κB activation and inhibition of glucose-stimulated insulin secretion (GSIS).
CFN90160 Methysticin

Methysticin is a potent NF-kappaB inhibitor in kava with minimum toxicity, it possesses hepatotoxic, anticonvulsant and neuroprotective properties, it contributes to CYP1A1 induction.
CFN97472 Neochlorogenic acid

Neochlorogenic acid shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
CFN90163 (+)-Catechin hydrate

(+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
CFN90171 Polygalasaponin F

Polygalasaponin F possesses anxiolytic and sedative-hypnotic activities, and has cognition improving and cerebral protective effects. Polygalasaponin F can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway.