Bioactive Products
| A unique collection of 223 Neuroprotection natural compounds for high throughput screening (HTS) | ||
| Catalog No: | B72a21 | Neuroprotection Compound Library Screening Details |
| Size: | 1mg/well * 223 Compounds 2mg/well * 223 Compounds | |
| Cat. No. | Information |
| CFN93217 | alpha-Asarone alpha-Asarone has antioxidant activity, it effectively reversed MDR by inhibiting P-gp function and expression. alpha-Asarone protects against Ang II-mediated damage of endothelial cells and may be developed to prevent injury to cardiovascular tissues. Alpha-asarone congeners as hypolipidemic agents, they appeared to be promising for the treatment of human hyperlipidaemia and thrombotic diseases.Alpha-asarone also attenuates depression-like behavior in nicotine-withdrawn mice. |
| CFN93215 | Kukoamine A Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats. Kukoamine A prevents radiation-induced neuroinflammation and preserves hippocampal neurogenesis in rats by inhibiting activation of NF-κB and AP-1. It attenuates insulin resistance and fatty liver through downregulation of Srebp-1c. |
| CFN93212 | Panaxynol Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. Panaxynol has neuroprotective, and anti-proliferative effects, it induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms, and protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade. Panaxynol has inhibitory effects on the proliferation of human pancreatic cancer cell PANC-1through inhibiting cell division and down-regulating Ki67 expression. |
| CFN92452 | 2'-Acetylacteoside 2'-Acetylacteoside has antioxidative, hepatoprotective, and neuroprotective activities. 2'-Acetylacteoside (0.071 uM) demonstrates potent rat lens aldose reductase inhibitory activity; it can significantly suppress NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. |
| CFN93216 | Kukoamine B Kukoamine B is a potent dual inhibitor for both Lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA), LPS and CpG DNA are important pathogenic molecules for the induction of sepsis,are drug targets for sepsis treatment, thus kukoamine B is worthy of further investigation as a potential candidate to treat sepsis. Kukoamine B may potentially serve as an agent for prevention of several human neurodegenerative and other disorders caused by oxidative stress, it has protective effects against hydrogen peroxide (H2O2) induced cell injury and potential mechanisms in SH-SY5Y cells. |
