Product informatin DBs
Chrysophanol
Chrysophanol has anti-inflammatory activity through the suppression of NF-κB/caspase-1 activation in vitro and in vivo.[1] Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.[2] Chrysophanol has mild cytotoxicity and ant...
Ellagic acid
Ellagic acid, a naturally occurring plant phenol, inhibits the activity of the direct-acting mutagen N-methyl-N-nitrosourea (MeNU) in Salmonella typhimurium TA100, is due to specific inhibition of methylation at the O6 position of guanine through an ellagic acid-duplex DNA affinity-binding m...
Hyperoside
Hyperoside, a flavonoid glycoside isolated from Artemisia capillaris, has protective effects against CCl4-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.[1] Hyperoside can protect A&bet...
Isoimperatorin
Isoimperatorin is a medicinal herbal product that is isolated from the dried roots of Angelicae dahuricae ,can inhibit the cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D 2 (PGD 2 ) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner, wit...
Procyanidin C1
In vitro, procyanidin C1 (PC1) dose-dependently decreased Fc epsilon RI-mediated degranulation and cytokine production of mast cells, inhibited tyrosine phosphorylation of Syk and linker for activation of T cells, and the ROS generation in stimulated mast cells.PC1 suppresses Fc epsilon RI-m...
Arctigenin
Arctigenin, naturally occurring in Bardanae fructus, Saussurea medusa, Arctium lappa L., Torreya nucifera and Ipomea cairica, is a phenylpropanoid dibenzylbutyrolactone lignan with antioxidant and anti-inflammatory activities, it can potently inhibit the activity of MKK1 in vitro with the IC...
Ferulic acid
Ferulic acid is the most abundant hydroxycinnamic acid in the plant world and maize bran with 3.1% (w/w) ferulic acid, is an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications, shows antioxidant activity in parallel with thei...
6-Shogaol
6-Shogaol, an active constituent of ginger, is a potent inhibitor of MDA-MB-231 cell invasion, and the molecular mechanism involves at least in part the down-regulation of MMP-9 transcription by targeting the NF-κB activation cascade, thus has potential for clinical use as antimetastatic tr...
Aloeemodin
Aloeemodin is able to interact with DNA under certain in vitro conditions, however, in vivo it is negative did not indicate a genotoxic potential, thus, it may be assumed that a genotoxic risk for man might be unlikely.[1] Aloeemodin has inhibition of β-amyloid aggregation, and ha...
Imperatorin
Imperatorin, a biologically active furanocoumarin from the roots of Angelica dahurica (Umbelliferae), can induce apoptosis in human promyelocytic leukaemia, HL-60 cells, and induces apoptosis was significantly blocked by Z-VAD-FMK (a broad spectrum caspase inhibitor), Z-LEHD-FMK (a caspase-9 inh...