1-Kestose | CAS:470-69-9 | Manufacturer ChemFaces

1-Kestose

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $18.7 / In-stock
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Description:

1-Kestose shows significant anti-hydroxyl radical potential. 1-Kestose can promote intestinal Lactobacillus number, and influence the microorganisms as well as the intestinal and systemic immune responses.

Targets:

IFN-γ | IL Receptor

In vitro:

Applied Microbiology & Biotechnology, 1991, 35(2):216-221.

Production of 1-kestose with intact mycelium of Aspergillus phoenicis containing sucrose-1 F -fructosyltransferase[Reference: WebLink]

METHODS AND RESULTS:
Favourable reaction conditions for the enzymatic production of 1-Kestose by sucrose-1F-fructosyltransferase, SFT (EC 2.4.1.99) from Aspergillus phoenicis CBS 294.80 mycelium were established. The intracellular enzyme SFT works best at 60C, exhibits a relatively high thermostability and possesses an alkaline pH optimum. An invertase also present in the mycelium of A. phoenicis possesses an acidic pH optimum.
CONCLUSIONS:
Consequently, around pH 8.0 sucrose is converted mainly to 1-Kestose and nystose while fructose is only formed in relatively small amounts. Under optimal conditions (55 C, pH 8.0 and an initial sucrose concentration of 750 g 1-1) a yield of about 300 g 1-Kestose per 1.01 reaction mixture could be achieved after 8 h.

International Journal of Food Science & Technology, 2014, 49(6):1500-1505.

In vitro anti‐hydroxyl radical activity of the fructooligosaccharides 1‐kestose and nystose using spectroscopic and computational approaches[Reference: WebLink]

Fructooligosaccharides (FOS) are bioactive oligosaccharide fructans with beneficial health effects. Anti‐hydroxyl radical activity is an important factor in the description of antioxidant capacity of any natural product. The aim of this study was to estimate in vitro anti‐hydroxyl radical activity of the FOS 1-Kestose and nystose by electron paramagnetic resonance spectroscopy (EPR) and fluorescence spectroscopy (FS) followed by a theoretical approach based on quantum chemistry calculations.
METHODS AND RESULTS:
A significant anti‐hydroxyl radical potential of both compounds was observed (72% and 78% by EPR and 69% and 74% by FS, respectively), indicating the nystose to be a more active natural product. In addition, the computational results have confirmed that nystose follows the same pattern previously shown for 1-Kestose, that is, that carbohydrates can react with hydroxyl radical.
CONCLUSIONS:
It is well known that FOS belong to cardioprotective nutraceuticals, so the study may be of some interest to research in heart disease.

1-Kestose Description

Source:	The herbs of Hordeum vulgare L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Journal of Applied Glycoscience, 2006, 53(3):175-180.

Effects of 1-kestose and nystose on the intestinal microorganisms and immune system in mice. [Reference: WebLink]

We investigated the effects of the major short chain fructooligosaccharides, 1-Kestose and nystose, on the intestinal microorganisms and on the intestinal and systemic immune responses of mice.
METHODS AND RESULTS:
Both 1-Kestose and nystose promoted intestinal Lactobacillus number. However, the balance of Lb. reuteri and Lb. intestinalis, the major Lactobacillus species in the mice was not altered. The IgA content in the feces of mice treated with both 1-Kestose and nystose increased from day 4 to day 7 after starting the administration and returned to the same level of control mice on day 14. Splenocyte responses to Con A, anti-CD3 plus anti-CD28 antibodies and LPS were reduced by 1-Kestose and nystose. Nystose lowered IL-2, IFN-γ, IL-12 and IL-4 secretion from the splenocytes more than 1-Kestose.
CONCLUSIONS:
These results suggested that both 1-Kestose and nystose can influence the microorganisms as well as the intestinal and systemic immune responses, but to different degrees.

Product Name	1-Kestose
Price:	$60 / 20mg
CAS No.:	470-69-9
Catalog No.:	CFN93069
Molecular Formula:	C₁₈H₃₂O₁₆
Molecular Weight:	504.43 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The herbs of Hordeum vulgare L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library IL Receptor Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9824 mL	9.9122 mL	19.8244 mL	39.6487 mL	49.5609 mL
5 mM	0.3965 mL	1.9824 mL	3.9649 mL	7.9297 mL	9.9122 mL
10 mM	0.1982 mL	0.9912 mL	1.9824 mL	3.9649 mL	4.9561 mL
50 mM	0.0396 mL	0.1982 mL	0.3965 mL	0.793 mL	0.9912 mL
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.3965 mL	0.4956 mL

CFN98970	Sucrose	57-50-1	342.3	C₁₂H₂₂O₁₁
CFN91716	D-Trehalose	99-20-7	342.30	C₁₂H₂₂O₁₁
CFN90425	Raffinose	17629-30-0	594.51	C₁₈H₃₂O₁₆(₅H₂O)
CFN98574	Nystose	13133-07-8	666.58	C₂₄H₄₂O₂₁
CFN90424	Stachyose	10094-58-3	666.57	C₂₄H₄₂O₂₁
CFN91170	Acarbose	56180-94-0	645.6	C₂₅H₄₃NO₁₈
CFN91550	Maltotriose	1109-28-0	504.4	C₁₈H₃₂O₁₆
CFN90871	Maltotetraose	34612-38-9	666.6	C₂₄H₄₂O₂₁
CFN91478	Maltopentaose	34620-76-3	828.7	C₃₀H₅₂O₂₆
CFN90872	Maltohexaose	34620-77-4	990.9	C₃₆H₆₂O₃₁