Schinifoline | CAS:80554-58-1 | Manufacturer ChemFaces

Schinifoline

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Size /Price /Stock	10 mM * 1 mL in DMSO / $103.7 / In-stock
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Description:

Schinifoline has cytotoxic activity, it also shows in vitro radiosensitising, cell cycle and apoptotic-inducing effects.

In vitro:

Molecules. 2014 Dec 1;19(12):20128-38.

Radiosensitizing effect of schinifoline from Zanthoxylum schinifolium Sieb et Zucc on human non-small cell lung cancer A549 cells: a preliminary in vitro investigation.[Pubmed: 25470278 ]

Schinifoline (SF), a 4-quinolinone derivative, was found in Zanthoxylum schinifolium for the first time. 4-Quinolinone moieties are thought to have cytotoxic activity and are often used as a tubulin polymerization inhibitors, heterogeneous enzyme inhibitors and antiplatelet agents. However, very little information respect to radiosensitization has focused on SF.
METHODS AND RESULTS:
This work aimed to investigate the radiosensitizing effect of SF on A549 cells. The cell viability results indicated cytotoxicity of SF on A549 cells, with IC50 values of 33.7 ± 2.4, 21.9 ± 1.9 and 16.8 ± 2.2 μg/mL, respectively, after 6, 12, 24 h treatment with different concentrations, and the 10% or 20% IC50 concentration during 12 h was applied in later experiments. The results of cell proliferative inhibition and clonogenic assay showed that SF enhanced the radiosensitivity of A549 cells when applied before 60Co γ-irradiation and this effect was mainly time and concentration dependent. The flow cytometric data indicated that SF treatment before the irradiation increased the G2/M phase, thus improving the radiosensitivity of A549, leading to cell apoptosis.
CONCLUSIONS:
This paper is the first study that describes the in vitro radiosensitising, cell cycle and apoptotic-inducing effects of Schinifoline.

Schinifoline Description

Source:	The herbs of Capsicum annuum L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Schinifoline
Price:	$228 / 10mg
CAS No.:	80554-58-1
Catalog No.:	CFN97283
Molecular Formula:	C₁₇H₂₃NO
Molecular Weight:	257.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Capsicum annuum L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Pro-apoptotic Compound Library Chemosensitizers Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.885 mL	19.425 mL	38.85 mL	77.7001 mL	97.1251 mL
5 mM	0.777 mL	3.885 mL	7.77 mL	15.54 mL	19.425 mL
10 mM	0.3885 mL	1.9425 mL	3.885 mL	7.77 mL	9.7125 mL
50 mM	0.0777 mL	0.3885 mL	0.777 mL	1.554 mL	1.9425 mL
100 mM	0.0389 mL	0.1943 mL	0.3885 mL	0.777 mL	0.9713 mL

CFN89147	Arborinine	5489-57-6	285.29	C₁₆H₁₅NO₄
CFN89259	Rutacridone	17948-33-3	307.34	C₁₉H₁₇NO₃
CFN99672	Sambutoxin	160047-56-3	453.6	C₂₈H₃₉NO₄
CFN98094	1-Methyl-2-pentyl-4(1H)-quinolinone	22048-98-2	229.3	C₁₅H₁₉NO
CFN97283	Schinifoline	80554-58-1	257.4	C₁₇H₂₃NO
CFN96290	1-Methyl-2-nonylquinolin-4(1H)-one	68353-24-2	285.4	C₁₉H₂₇NO
CFN96296	1-Methyl-2-undecylquinolin-4(1H)-one	59443-02-6	313.5	C₂₁H₃₁NO
CFN96758	(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one	120693-49-4	311.46	C₂₁H₂₉NO
CFN96759	Evocarpine	15266-38-3	339.52	C₂₃H₃₃NO
CFN92786	Dihydroevocarpine	15266-35-0	341.5	C₂₃H₃₅NO