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Isogambogic acid
Isogambogic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isogambogic acid
Price: $318 / 10mg
CAS No.: 149655-52-7
Catalog No.: CFN95440
Molecular Formula: C38H44O8
Molecular Weight: 628.8 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The herbs of Garcinia hanburyi Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $251.2 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isogambogic acid shows cytotoxic activiity against KB and drug-resistant KB-V1 cell lines. Isogambogic acid has anticancer activity.
In vitro:
Magnetic Resonance in Chemistry. April 1993 31(4):340 - 347
Isogambogic acid and isomorellinol from Garcinia hanburyi[Reference: WebLink]
Three xanthone derivatives, gambogic acid, Isogambogic acid and isomorellinol, were isolated from the dried latex of Garcinia hanburyi. Two of them, Isogambogic acid and isomorellinol, are new. Determinations of the structures and stereochemistry were achieved independently by a series of NMR experiments including COSY, ROESY, HMQC, HMBC and selective INEPT. Isolation of isomorellinol from G. hanburyi provided important chemical evidence to link this species to G. morella. The presence of gambogic acid and Isogambogic acid, however, demonstrated the difference between these two species. Cytotoxic evaluation of these isolates revealed that all three were active against KB and drug-resistant KB-V1 cell lines.
Isogambogic acid Description
Source: The herbs of Garcinia hanburyi Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5903 mL 7.9517 mL 15.9033 mL 31.8066 mL 39.7583 mL
5 mM 0.3181 mL 1.5903 mL 3.1807 mL 6.3613 mL 7.9517 mL
10 mM 0.159 mL 0.7952 mL 1.5903 mL 3.1807 mL 3.9758 mL
50 mM 0.0318 mL 0.159 mL 0.3181 mL 0.6361 mL 0.7952 mL
100 mM 0.0159 mL 0.0795 mL 0.159 mL 0.3181 mL 0.3976 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Magnetic Resonance in Chemistry. April 1993 31(4):340 - 347
Isogambogic acid and isomorellinol from Garcinia hanburyi[Reference: WebLink]
Three xanthone derivatives, gambogic acid, Isogambogic acid and isomorellinol, were isolated from the dried latex of Garcinia hanburyi. Two of them, Isogambogic acid and isomorellinol, are new. Determinations of the structures and stereochemistry were achieved independently by a series of NMR experiments including COSY, ROESY, HMQC, HMBC and selective INEPT. Isolation of isomorellinol from G. hanburyi provided important chemical evidence to link this species to G. morella. The presence of gambogic acid and Isogambogic acid, however, demonstrated the difference between these two species. Cytotoxic evaluation of these isolates revealed that all three were active against KB and drug-resistant KB-V1 cell lines.
CFN92089Gambogin173792-67-1598.8C38H46O6
CFN92098Epigambogic acid887606-04-4628.8C38H44O8
CFN9210130-Hydroxygambogic acid881027-36-7644.8C38H44O9
CFN920999R-10alpha-Hydroxyepigambogic acid1097882-33-1646.8C38H46O9
CFN9210010alpha-Hydroxyepigambogic acid1164201-85-7646.8C38H46O9
CFN95439Gambogoic acid A887923-49-1660.8C39H48O9
CFN92957Gambogoic acid B887923-50-4674.82C40H50O9
CFN95458Gambogic acid A1592842-93-7676.8C39H48O10
CFN93214Gambogellic acid173867-04-4628.76C38H44O8
CFN95438Epigambogellic acid1352191-85-5628.8C38H44O8
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