- ChemFaces is a professional high-purity natural products manufacturer.
- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
ChemFaces products have been cited in many studies from excellent and top scientific journals
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
- Pharmacol Res.2020, 161:105205.
- Phytomedicine.2024, 129:155645.
- Processes2020, 8(12),1540.
- Chemistry of Natural Compounds...2020...
- Phytomedicine.2021, 83:153483.
- Mutlu Yanic S, Ates EG. JOTCSA....2023...
- Heliyon.2023, e12778.
- J.the Korean Socie. Food Sci.&Nut...2023...
- Biomed Pharmacother.2023, 162:114617.
- Antioxidants (Basel).2020, 9(6):544.
- Cancers (Basel).2021, 13(17):4327.
- J Ethnopharmacol.2019, 235:406-414
- Oncotarget.2016, 8(51):88386-88400
- J of Applied Biological Chem....2020...
- FUTURE VIROLOGYVOL.2023, 18(5).
- Foods. 2022, 11(23):3905.
- J Biochem Mol Toxicol.2022, e23211.
- Sci Rep.2019, 9(1):4646
- Front Pharmacol.2022, 13:883475.
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- Pharmacol Rep.2020, 72(2):472-480.
- Indian J Pharm Sci.2022, 84(3):144-151
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Our products had been exported to the following research institutions and universities, And still growing.
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- Washington State University (USA)
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- University of Illinois at Chicago (USA)
- Heidelberg University (Germany)
- Utrecht University (Netherlands)
- Sapienza University of Rome (Italy)
- University of South Australia (Australia)
- University of Liège (Belgium)
- Kyushu University (Japan)
- National Cancer Institute (USA)
- More...
- Anat Rec (Hoboken).2021, 304(2):323-332.
- Arch Toxicol.2017, 91(10):3225-3245
- Biomed Pharmacother.2021, 137:111362.
- Applied Biological Chem. 2020, 26(63).
- Int J Oncol.2016, 49(4):1497-504
- Foods.2021, 10(11):2754.
- J Ethnopharmacol.2024, 318:116863.
- Pharm Biomed Res2023, 9(3):173-182.
- Mol Immunol. 2016, 78:121-132
- Journal of Functional Foods2019, 52:430-441
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
2,3,9,10-Tetrahydroxyberberine chloride shows antioxidant activity. |
| In vitro: |
| Asian Pacific journal of cancer prevention: APJCP, 2015, 16(13):5371-5376. | | Antioxidant Effect of Berberine and its Phenolic Derivatives Against Human Fibrosarcoma Cells.[Reference: WebLink] |
METHODS AND RESULTS:
Berberine (B1), isolated from stems of Coscinium fenestratum (Goetgh.) Colebr, was used as a principle structure to synthesize three phenolic derivatives: berberrubine (B2) with a single phenolic group, berberrubine chloride (B3) as a chloride counter ion derivative, and 2,3,9,10-Tetrahydroxyberberine chloride (B4) with four phenolic groups, to investigate their direct and indirect antioxidant activities. For DPPH assay, compounds B4, B3, and B2 showed good direct antioxidant activity (IC50 values=10.7±1.76, 55.2±2.24, and 87.4±6.65 μM, respectively) whereas the IC50 value of berberine was higher than 500 μM. Moreover, compound B4 exhibited a better DPPH scavenging activity than BHT as a standard antioxidant (IC50=72.7±7.22 μM) due to the ortho position of hydroxyl groups and its capacity to undergo intramolecular hydrogen bonding.
CONCLUSIONS:
For cytotoxicity assay against human fibrosarcoma cells (HT1080) using MTT reagent, the sequence of IC50 value at 7-day treatment stated that B1. |
|
2,3,9,10-Tetrahydroxyberberine Description
| Source: |
The rhizomes of Coptis chinensis Franch. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.375 mL |
16.8748 mL |
33.7496 mL |
67.4992 mL |
84.3739 mL |
| 5 mM |
0.675 mL |
3.375 mL |
6.7499 mL |
13.4998 mL |
16.8748 mL |
| 10 mM |
0.3375 mL |
1.6875 mL |
3.375 mL |
6.7499 mL |
8.4374 mL |
| 50 mM |
0.0675 mL |
0.3375 mL |
0.675 mL |
1.35 mL |
1.6875 mL |
| 100 mM |
0.0337 mL |
0.1687 mL |
0.3375 mL |
0.675 mL |
0.8437 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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