27-p-Coumaroyloxyursolic acid | CAS:73584-67-5

27-p-Coumaroyloxyursolic acid

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Description:

27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay.

In vitro:

J Nat Prod. 1999 Jul;62(7):1061-4.

Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha.[Pubmed: 10425145 ]

METHODS AND RESULTS:
Activity-guided fractionation of a methanol extract of the leaves of Ilex kudincha led to the isolation of seven acyl CoA cholesteryl acyl transferase (ACAT) inhibitory triterpenes. Four of them were identified by spectroscopic methods as ulmoidol (4), 23-hydroxyursolic acid (5), 27-trans-p-coumaroyloxyursolic acid (6), and 27-cis-p-coumaroyloxyursolic acid (7), and three were new compounds named ilekudinols A-C (1-3). The structures of these new triterpenoids were elucidated as 2alpha, 3beta-dihydroxy-24-nor-urs-4(23),11-dien-28,13beta- olide (1), 2alpha, 3beta-dihydroxy-24-nor-urs-4(23),12-dien-28-oic acid (2), and 3beta, 24,28-trihydroxylupane (3).
CONCLUSIONS:
Compounds 1-7 showed potent inhibitory activity in the ACAT assay.

27-p-Coumaroyloxyursolic acid Description

Source:	The herbs of Viburnum cylindricum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Planta Med. 2001 Oct;67(7):683-4.

Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid.[Pubmed: 11582553 ]

METHODS AND RESULTS:
The triterpenes ursolic acid (1), 27-p-Z-coumaroyloxyursolic acid (2), 27-p-E-coumaroyloxyursolic acid, alpha-amyrine-3-palmitate and lupeol-3-palmitate were isolated through a bioactivity-guided fractionation from the acetonic extract of the aerial parts of Viburnum jucundum Morton in addition to amentoflavone, an epimeric mixture at C-2 of 2,3-dihydroamentoflavone, beta-sitosterol and beta-sitosteryl glucopyranoside.
CONCLUSIONS:
Ursolic acid (1) was the only constituent that exhibited cytotoxic activity toward three human cancer cell lines in culture. This is the first phytochemical and cytotoxic analysis performed to this plant species.

Product Name	27-p-Coumaroyloxyursolic acid
Price:
CAS No.:	73584-67-5
Catalog No.:	CFN97217
Molecular Formula:	C₃₉H₅₄O₆
Molecular Weight:	618.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Viburnum cylindricum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6158 mL	8.0788 mL	16.1577 mL	32.3154 mL	40.3942 mL
5 mM	0.3232 mL	1.6158 mL	3.2315 mL	6.4631 mL	8.0788 mL
10 mM	0.1616 mL	0.8079 mL	1.6158 mL	3.2315 mL	4.0394 mL
50 mM	0.0323 mL	0.1616 mL	0.3232 mL	0.6463 mL	0.8079 mL
100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.3232 mL	0.4039 mL

CFN97217	27-p-Coumaroyloxyursolic acid	73584-67-5	618.9	C₃₉H₅₄O₆
CFN98694	Quinovic acid	465-74-7	486.7	C₃₀H₄₆O₅
CFN99060	Quinovic acid 3-O-alpha-L-rhamnopyranoside	104055-76-7	632.8	C₃₆H₅₆O₉
CFN99084	Quinovin	107870-05-3	632.8	C₃₆H₅₆O₉
CFN99850	Quinovic acid 3-O-(3',4'-O-isopropylidene)-beta-D-fucopyranoside	182132-59-8	672.9	C₃₉H₆₀O₉
CFN97273	Quinovic acid 3-O-beta-D-glucoside	79955-41-2	648.8	C₃₆H₅₆O₁₀
CFN99801	Rubelloside B	167875-39-0	795.0	C₄₂H₆₆O₁₄
CFN99361	Quinovic acid 3-O-(6-deoxy-beta-D-glucopyranoside) 28-O-beta-D-glucopyranosyl ester	124727-10-2	795.0	C₄₂H₆₆O₁₄